{"id":"W1699214082","doi":"10.1038/ng.3293","title":"A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":244,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute","keywords":"Osteosarcoma; Biology; Metastasis; Cancer research; Gene; ErbB; PI3K/AKT/mTOR pathway; Genetic screen; Genome instability; Signal transduction; Cancer; Genetics; Phenotype; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938142,0.0002788637,0.0003906494,0.0001486087,0.0001218634,0.00008170356,0.00008880722,0.0002364785,0.000008755569],"category_scores_gemma":[0.00008076239,0.0002341036,0.00006133848,0.0001563479,0.00005991017,0.00004847855,0.0002039617,0.0002315036,0.000008240586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000836529,"about_ca_system_score_gemma":0.000228373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005452478,"about_ca_topic_score_gemma":0.0002193,"domain_scores_codex":[0.9984127,0.00003703145,0.0003136134,0.0004442447,0.0004279486,0.0003644466],"domain_scores_gemma":[0.9988657,0.0000658225,0.00008882416,0.0002971792,0.0001299845,0.0005525516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00003102643,0.00009535614,0.4954265,0.00006534469,0.0003321673,0.0001602689,0.001433919,0.000005525425,0.0007747845,0.00003421748,0.0008013168,0.5008396],"study_design_scores_gemma":[0.003185955,0.0002960896,0.8953065,0.0001957314,0.0007547229,0.0004387946,0.0006130642,0.0002214643,0.05609942,0.0006135843,0.04184758,0.0004271014],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8577332,0.1406956,0.0002354425,0.0006104699,0.0001598617,0.0003827813,0.000007985385,0.00004742671,0.0001272506],"genre_scores_gemma":[0.9096992,0.001547099,0.08786114,0.0004466399,0.0002293744,0.00002450206,0.00002899278,0.0000391816,0.0001238901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5004125,"threshold_uncertainty_score":0.9546469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03405641952822479,"score_gpt":0.2774755764577278,"score_spread":0.243419156929503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}