{"id":"W1702758641","doi":"10.1007/s12668-017-0488-x","title":"Preventing Common Hereditary Disorders through Time-Separated Twinning","year":2018,"lang":"en","type":"preprint","venue":"BioNanoScience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Beijing Institute of Genomics, Chinese Academy of Sciences; Université de Montréal; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Genetics; Mendelian inheritance; Disease; Population; Genetic load; Sibling; Biology; Medicine; Gene; Psychology; Internal medicine; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007131022,0.0004592665,0.0004407102,0.0006224251,0.0004043936,0.0003709172,0.0006007359,0.0006255115,0.003313125],"category_scores_gemma":[0.001430691,0.0002193713,0.0005989767,0.000395677,0.0005434515,0.0004317889,0.001034752,0.0009976156,0.0002864245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312625,"about_ca_system_score_gemma":0.00042582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005870006,"about_ca_topic_score_gemma":0.000822297,"domain_scores_codex":[0.9995696,0.000120312,0.0000334121,0.0001106963,0.0001122501,0.00005378985],"domain_scores_gemma":[0.9995124,0.0001649887,0.0001082095,0.0001070637,0.00004123149,0.00006611043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003270738,0.0007715556,0.00984644,0.0004768925,0.0004061734,0.002185173,0.0004771629,0.004776914,0.7130946,0.02143852,0.002255768,0.241],"study_design_scores_gemma":[0.0006624229,0.003450834,0.01900471,0.0003230416,0.001323909,0.01714193,0.0003774424,0.01524774,0.8771199,0.02196384,0.04330136,0.00008286839],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8249158,0.009890919,0.154932,0.00122757,0.0004146275,0.0002095234,0.0002843933,0.0005615163,0.007563736],"genre_scores_gemma":[0.9583572,0.003465082,0.03265456,0.0002033935,0.00005486884,0.00008244176,0.0002186043,0.0001158056,0.004848089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003313125,"threshold_uncertainty_score":0.01108348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051787280721168,"score_gpt":0.3075428098937193,"score_spread":0.2870249370865076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}