{"id":"W1704277699","doi":"","title":"Phase I study of everolimus, cetuximab and irinotecan as second-line therapy in metastatic colorectal cancer.","year":2015,"lang":"en","type":"article","venue":"PubMed","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"","keywords":"Everolimus; Irinotecan; Cetuximab; Medicine; Capecitabine; Oxaliplatin; Colorectal cancer; Internal medicine; Oncology; Dosing; Toxicity; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002238517,0.001741552,0.002200466,0.0006009527,0.0004219233,0.0009515773,0.001075664,0.001338647,0.003781274],"category_scores_gemma":[0.00103813,0.0009788717,0.001351171,0.0005428474,0.0009122828,0.0008135061,0.0003515712,0.003180277,0.0006262294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176807,"about_ca_system_score_gemma":0.00239915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00155341,"about_ca_topic_score_gemma":0.005486791,"domain_scores_codex":[0.999283,0.0003616649,0.00003856004,0.0001041665,0.00007491766,0.0001376156],"domain_scores_gemma":[0.9988097,0.0001879985,0.0002212822,0.00007977874,0.00006336564,0.0006380209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7697226,0.09738211,0.005084172,0.000981867,0.001769633,0.0002980471,0.0002809288,0.003827174,0.0538508,0.0003392038,0.002655925,0.06380752],"study_design_scores_gemma":[0.5193824,0.4670517,0.00560228,0.00002862917,0.0004448246,0.0001888486,0.00002912248,0.0007113013,0.004548681,0.00007678989,0.0019187,0.00001674404],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888902,0.003474692,0.0005978453,0.0004244572,0.0001713044,0.004038416,0.0007056156,0.00007162904,0.001625876],"genre_scores_gemma":[0.9851032,0.002943842,0.002964189,0.0006607008,0.0002567324,0.003462021,0.001774862,0.00002800612,0.002806464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003781274,"threshold_uncertainty_score":0.0126496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07258802844246125,"score_gpt":0.3432767271160648,"score_spread":0.2706886986736036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}