{"id":"W1704515184","doi":"10.1002/bies.201400073","title":"Defining ‘medical necessity’ in an age of personalised medicine: A view from Canada","year":2014,"lang":"en","type":"article","venue":"BioEssays","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Alberta","funders":"Canadian Institutes of Health Research; Genome Alberta","keywords":"Health care; Healthcare system; Business; Medicine; Engineering ethics; Political science; Law; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488274,0.00009283175,0.0001632646,0.00002676833,0.00002518625,0.000004273354,0.0002322475,0.0001183632,0.0002035446],"category_scores_gemma":[0.000265739,0.00008348991,0.00002060974,0.00009280195,0.0001156873,0.000002218935,0.00005076042,0.00007447322,0.000001184602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004560753,"about_ca_system_score_gemma":0.00062024,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1828392,"about_ca_topic_score_gemma":0.603945,"domain_scores_codex":[0.9990657,0.0001019803,0.0002055651,0.0002405909,0.0002479796,0.0001381687],"domain_scores_gemma":[0.9994975,0.00003900284,0.00006542536,0.0002586866,0.00004476061,0.00009456678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002247953,0.0002555512,0.3076709,0.0002194372,0.0001649415,0.00009812262,0.001812309,0.0001720202,0.5677147,0.002844317,0.03467244,0.08415049],"study_design_scores_gemma":[0.009424735,0.001271951,0.4156735,0.001033291,0.0001493073,0.00003169603,0.003053276,0.003454016,0.1567928,0.001646784,0.4058258,0.001642822],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944187,0.001689701,0.0005134231,0.0007744107,0.0002422052,0.00005731088,0.00004041622,0.000004722678,0.002259057],"genre_scores_gemma":[0.9976715,0.00005921241,0.0005460322,0.001049828,0.0002232087,0.00001154545,0.0003993067,0.00001176082,0.00002760087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4211058,"threshold_uncertainty_score":0.8226024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172616109505015,"score_gpt":0.2758140443752572,"score_spread":0.264087883280207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}