{"id":"W1705794095","doi":"10.1002/cbic.201500297","title":"Changing Biosynthetic Profiles by Expressing <i>bldA</i> in <i>Streptomyces</i> Strains","year":2015,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Deutsche Forschungsgemeinschaft","keywords":"Complementation; Streptomyces; Gene cluster; Gene; Biology; Actinomycetales; Biosynthesis; Phenotype; Chemistry; Genetics; Stereochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003226342,0.0002303137,0.000335886,0.000143084,0.0000478435,0.00004062508,0.0001386382,0.000165013,0.00007685813],"category_scores_gemma":[0.0002331748,0.0001876083,0.00007900751,0.0004350196,0.0001034965,0.0001010636,0.00008530216,0.0002434371,0.00004567644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078636,"about_ca_system_score_gemma":0.00009895651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001588784,"about_ca_topic_score_gemma":0.000001446354,"domain_scores_codex":[0.9985235,0.0000236281,0.0002775728,0.0004567612,0.0002324059,0.0004861058],"domain_scores_gemma":[0.9992494,0.00001955785,0.00008585396,0.0003352802,0.00008530785,0.0002246135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004486769,0.0001512574,0.0003441743,0.0001010129,0.00001402174,0.00002213781,0.0004565779,1.899354e-7,0.9753173,0.00001147343,0.01928091,0.00425606],"study_design_scores_gemma":[0.0008690562,0.00005175537,0.00005467798,0.0003146578,0.00002818911,0.00004879212,0.0007846213,0.00002027856,0.9869645,0.00003290477,0.01060172,0.0002288026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878116,0.00197062,0.000007056382,0.003285886,0.0001539888,0.000346431,0.00003964243,0.0001118585,0.006272923],"genre_scores_gemma":[0.9961237,0.00003243758,0.0006221581,0.0006925317,0.0002858247,0.000003970498,0.00009021932,0.00003465103,0.002114488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164722,"threshold_uncertainty_score":0.7650443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137279546395446,"score_gpt":0.2511980149892153,"score_spread":0.2298252195252609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}