{"id":"W1706676225","doi":"10.1006/excr.1999.4789","title":"Increased Activity of the Protein Kinase C-δ Holoenzyme in the Cytoplasmic Particulate Fraction Precedes the Activation of Caspases in Polyomavirus-Transformed pyF111 Rat Fibroblasts Exposed to Calphostin C or Topoisomerase-II Inhibitors","year":2000,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Biology; Calphostin C; Protein kinase C; Cytochrome c; Apoptosis; Calphostin; Molecular biology; Caspase; Cytosol; Topoisomerase; Cytoplasm; Cell biology; Kinase; Biochemistry; Programmed cell death; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404253,0.0004859762,0.000372531,0.0004003278,0.0003050391,0.0005494632,0.0002540663,0.0002907937,0.002505364],"category_scores_gemma":[0.0001562803,0.000228569,0.0004060148,0.0002781131,0.0003626124,0.0005202142,0.0001875263,0.001523489,0.0007303885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005623515,"about_ca_system_score_gemma":0.0004200317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198787,"about_ca_topic_score_gemma":0.001041828,"domain_scores_codex":[0.9998595,0.000009298331,0.00001126391,0.00003924814,0.00003184479,0.00004885097],"domain_scores_gemma":[0.9997107,0.00004862828,0.00005345638,0.00005104663,0.00004689984,0.0000891286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002050659,0.0000242295,0.0002057283,0.00003561635,0.000005566724,0.00006699422,0.0000232299,0.00001210322,0.9987692,0.0001209329,0.00001974006,0.0005114731],"study_design_scores_gemma":[0.00001946706,0.000179027,0.009414839,0.000007026108,0.0000124954,0.0003623425,0.00007507241,0.0001706726,0.9887999,0.0000910067,0.0008625234,0.00000566649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880559,0.003989442,0.004383622,0.0001997853,0.0001315253,0.00003475753,0.0009417023,0.0001037927,0.002159314],"genre_scores_gemma":[0.9913309,0.001409584,0.001617462,0.00005253517,0.00002635917,0.00003838291,0.001494028,0.00002726557,0.004003515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002505364,"threshold_uncertainty_score":0.008381248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04218049136921732,"score_gpt":0.3451078845886915,"score_spread":0.3029273932194742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}