{"id":"W1706676225","doi":"10.1006/excr.1999.4789","title":"Increased Activity of the Protein Kinase C-δ Holoenzyme in the Cytoplasmic Particulate Fraction Precedes the Activation of Caspases in Polyomavirus-Transformed pyF111 Rat Fibroblasts Exposed to Calphostin C or Topoisomerase-II Inhibitors","year":2000,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Biology; Calphostin C; Protein kinase C; Cytochrome c; Apoptosis; Calphostin; Molecular biology; Caspase; Cytosol; Topoisomerase; Cytoplasm; Cell biology; Kinase; Biochemistry; Programmed cell death; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007450195,0.0002087717,0.0002951806,0.0002403681,0.0002737108,0.00002532899,0.0002754102,0.0001364786,0.0003762917],"category_scores_gemma":[0.0002189349,0.0001029852,0.0001244527,0.001259801,0.0003410523,0.0001924206,0.00008331541,0.000589587,0.00001155062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002808502,"about_ca_system_score_gemma":0.0003308229,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006909489,"about_ca_topic_score_gemma":0.0005115212,"domain_scores_codex":[0.996963,0.0008443041,0.0004527057,0.000326355,0.0009289415,0.0004846447],"domain_scores_gemma":[0.9987326,0.0004792732,0.0000967984,0.0004915107,0.00006278323,0.000136981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009258485,0.002134793,0.002013352,0.00007391837,0.00001561415,0.00002843168,0.003367462,0.0000992334,0.9811608,0.000005088102,0.0002649445,0.001577848],"study_design_scores_gemma":[0.002166217,0.001363135,0.02458975,0.0005171756,0.00001298792,0.000007897868,0.002778507,0.0001593065,0.9680758,0.000008849118,0.0002090091,0.0001114125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948767,0.0003149028,6.054104e-7,0.001059194,0.00003170831,0.003101107,0.00001880435,0.00001408798,0.0005828955],"genre_scores_gemma":[0.9989359,0.00003671359,0.00001332498,0.00009676928,0.00004410997,0.0004285316,0.000008966898,0.00002451594,0.0004111764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0225764,"threshold_uncertainty_score":0.9997036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04218049136921732,"score_gpt":0.3451078845886915,"score_spread":0.3029273932194742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}