{"id":"W1710157178","doi":"10.1186/s12920-015-0093-1","title":"DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks","year":2015,"lang":"en","type":"article","venue":"BMC Medical Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Human genetics; Genetics; Schizophrenia (object-oriented programming); Gene; DNA methylation; Psychosis; Biology; DNA microarray; Methylation; Monozygotic twin; Computational biology; Bioinformatics; Psychology; Psychiatry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008268748,0.0001498433,0.0002043021,0.00006077663,0.00005204474,0.00003975342,0.0001459003,0.0002240532,0.000005651675],"category_scores_gemma":[0.000497987,0.0001329171,0.00005931138,0.00008799626,0.0001006042,0.000005706439,0.00008431852,0.00009164635,0.000001465549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002033988,"about_ca_system_score_gemma":0.0001416377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003109655,"about_ca_topic_score_gemma":0.0006388577,"domain_scores_codex":[0.998727,0.000130554,0.0003905793,0.0003588363,0.0001736269,0.0002194522],"domain_scores_gemma":[0.9993224,0.0001067156,0.000108432,0.0001962362,0.0000538994,0.0002123317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002510275,0.0005882219,0.4716253,0.0003530719,0.0003801573,0.00001419112,0.001307022,0.01300981,0.3165295,0.001615914,0.001058819,0.1910077],"study_design_scores_gemma":[0.01779428,0.002319305,0.2993607,0.0003538912,0.0003409164,0.00003223567,0.001931656,0.4839118,0.1471587,0.03492023,0.009314468,0.002561847],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.914279,0.008831669,0.07607639,0.0001072076,0.0003745017,0.0002748564,0.00000641481,0.000008906425,0.00004103813],"genre_scores_gemma":[0.9915908,0.002813117,0.005024561,0.0000363665,0.0002359577,0.00004915386,0.0001299814,0.00002164691,0.00009843933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.470902,"threshold_uncertainty_score":0.5420201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147247455644046,"score_gpt":0.2769881186276317,"score_spread":0.2455156440711913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}