{"id":"W1712426507","doi":"10.1002/stem.2012","title":"Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; Directorate for Biological Sciences; Peking Union Medical College; National Key Research and Development Program of China; Chinese Academy of Medical Sciences; National Natural Science Foundation of China; Ottawa Hospital Research Institute","keywords":"Reprogramming; SOX2; Biology; KLF4; Induced pluripotent stem cell; Sirtuin; Somatic cell; Embryonic stem cell; Cell biology; Stem cell; Acetylation; Sirtuin 1; Cellular differentiation; Genetics; Cell; Downregulation and upregulation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613791,0.0003375706,0.0002499331,0.0002119431,0.0001751632,0.0002600803,0.0001512923,0.0001953764,0.001376008],"category_scores_gemma":[0.0001051054,0.0001534354,0.0003541783,0.0001818951,0.0002122975,0.0001756114,0.0001826322,0.0003094825,0.0003404199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381125,"about_ca_system_score_gemma":0.0001574489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002873791,"about_ca_topic_score_gemma":0.0005046543,"domain_scores_codex":[0.9998708,0.00001768126,0.00001421899,0.00003707345,0.00003687893,0.00002343515],"domain_scores_gemma":[0.9999152,0.000007488121,0.00002898181,0.00001034461,0.0000120393,0.00002589898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028002,0.00001223542,0.001041417,0.00005315807,0.0000091289,0.0001196525,0.00001671322,0.0000538052,0.9955778,0.000236338,0.0000592449,0.002717727],"study_design_scores_gemma":[0.00002310439,0.0001312962,0.01983482,0.000008345538,0.00004613319,0.0005326089,0.00002661155,0.0009848747,0.9721116,0.0002527412,0.006040273,0.000007511755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762127,0.007757857,0.01093036,0.0002351226,0.0001211829,0.0000337804,0.0005607654,0.0001992735,0.003949129],"genre_scores_gemma":[0.9925646,0.00213034,0.001770393,0.00004951738,0.0000174425,0.00001554402,0.0005391366,0.00001853922,0.002894555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001376008,"threshold_uncertainty_score":0.004603207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854096010848333,"score_gpt":0.2709192270363722,"score_spread":0.2423782669278889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}