{"id":"W1712426507","doi":"10.1002/stem.2012","title":"Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; Directorate for Biological Sciences; Peking Union Medical College; National Key Research and Development Program of China; Chinese Academy of Medical Sciences; National Natural Science Foundation of China; Ottawa Hospital Research Institute","keywords":"Reprogramming; SOX2; Biology; KLF4; Induced pluripotent stem cell; Sirtuin; Somatic cell; Embryonic stem cell; Cell biology; Stem cell; Acetylation; Sirtuin 1; Cellular differentiation; Genetics; Cell; Downregulation and upregulation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005337184,0.0001563109,0.0001635523,0.00006710512,0.00003591814,0.00004705355,0.0002305545,0.0001779722,0.00001274211],"category_scores_gemma":[0.00002286323,0.0001569805,0.00006085311,0.0001496025,0.0000449426,0.000008303738,0.0001499703,0.0001188643,0.000147471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000062072,"about_ca_system_score_gemma":0.00009461796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008060296,"about_ca_topic_score_gemma":0.00005786859,"domain_scores_codex":[0.9984573,0.0001280542,0.0002865928,0.000436918,0.0003051998,0.0003859853],"domain_scores_gemma":[0.9991609,0.0000140743,0.00008351035,0.0004787219,0.0000874448,0.0001753253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003983307,0.00008401424,0.003896007,0.00005265406,0.00001870098,0.000005467656,0.0002306307,0.00006350108,0.9825969,0.000002824074,0.01038151,0.002627928],"study_design_scores_gemma":[0.0008185417,0.0001400728,0.00003289985,0.000017589,0.000004589979,0.000001911664,0.0004969454,0.0007598292,0.9725592,0.00002616146,0.02495438,0.0001879356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964065,0.00124006,0.0005374514,0.0001359856,0.00008967562,0.0004028059,0.00001664668,0.00002240684,0.001148485],"genre_scores_gemma":[0.9886557,0.0001026072,0.0005022881,0.0001221603,0.00006299998,0.00003759746,0.00008995466,0.00003408374,0.01039255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01457287,"threshold_uncertainty_score":0.640148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854096010848333,"score_gpt":0.2709192270363722,"score_spread":0.2423782669278889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}