{"id":"W1715606990","doi":"10.1089/hum.2015.059","title":"Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene","year":2015,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; U.S. Public Health Service; University College London; California Institute of Regenerative Medicine","keywords":"Transgene; Biology; Mutant; Simian immunodeficiency virus; Virology; Transduction (biophysics); Capsid; Gene; Cytotoxic T cell; Genetics; Human immunodeficiency virus (HIV); In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00057765,0.0005972011,0.000438422,0.0003323339,0.0002199599,0.0004309922,0.0006046627,0.0007283735,0.002132256],"category_scores_gemma":[0.0002684977,0.0001981562,0.0003769813,0.0001715657,0.0002641958,0.0003903703,0.0001754969,0.001535357,0.0004388407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732592,"about_ca_system_score_gemma":0.0004767996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007749493,"about_ca_topic_score_gemma":0.001051982,"domain_scores_codex":[0.9998373,0.00003786935,0.000009877227,0.00003112713,0.00003634878,0.00004744615],"domain_scores_gemma":[0.9998139,0.00003132258,0.00003806209,0.00002322282,0.00003110545,0.000062539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001932409,0.004046462,0.0002195514,0.0002016689,0.00004813815,0.0001492274,0.00008569066,0.0008085546,0.9811835,0.0005467098,0.0007594419,0.01001858],"study_design_scores_gemma":[0.0009235675,0.08785272,0.002274094,0.0000558712,0.0002405764,0.0007977398,0.00007956287,0.003083993,0.8875137,0.0003509429,0.01680098,0.00002629487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800856,0.004893362,0.007569574,0.0004196065,0.0002039759,0.000790211,0.001184415,0.0003380537,0.004515269],"genre_scores_gemma":[0.9812242,0.004743888,0.004958078,0.0002440668,0.00005670354,0.0006305392,0.002010836,0.00005254778,0.006079256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002132256,"threshold_uncertainty_score":0.007133126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1288889872679253,"score_gpt":0.4266104497153702,"score_spread":0.2977214624474449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}