{"id":"W1715606990","doi":"10.1089/hum.2015.059","title":"Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene","year":2015,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; U.S. Public Health Service; University College London; California Institute of Regenerative Medicine","keywords":"Transgene; Biology; Mutant; Simian immunodeficiency virus; Virology; Transduction (biophysics); Capsid; Gene; Cytotoxic T cell; Genetics; Human immunodeficiency virus (HIV); In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005361236,0.0002108522,0.0004390308,0.0001105438,0.0001938467,0.00001581079,0.0003406495,0.0001902708,0.002098127],"category_scores_gemma":[0.000008195304,0.0001651375,0.0001468868,0.00008364872,0.0002864416,0.00007013716,0.00003055788,0.0002450179,0.0004057855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005259401,"about_ca_system_score_gemma":0.0002341015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001499417,"about_ca_topic_score_gemma":0.00003574668,"domain_scores_codex":[0.9981358,0.0005231581,0.0004380405,0.0003776299,0.0001120675,0.0004132752],"domain_scores_gemma":[0.9990546,0.00004517655,0.0001092745,0.0005536773,0.0001166884,0.0001206156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002685222,0.001979184,0.01259612,0.000005429149,0.0004865379,0.00003330188,0.000947663,0.000006456354,0.9781646,0.0006719088,0.0007105113,0.004129783],"study_design_scores_gemma":[0.01616654,0.009793251,0.09381774,0.00001681167,0.00005063922,0.00006897719,0.0003096861,0.000002098163,0.8603064,0.001237767,0.01790297,0.000327135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945208,0.001776007,0.00006388085,0.0001067016,0.0001189887,0.0004633586,0.00009810887,0.00006287565,0.002789216],"genre_scores_gemma":[0.9972761,0.0002564536,0.0001654085,0.00006937455,0.00006455856,0.00004859056,0.0007645033,0.00002806928,0.001326983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1178582,"threshold_uncertainty_score":0.9988141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1288889872679253,"score_gpt":0.4266104497153702,"score_spread":0.2977214624474449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}