{"id":"W1719416134","doi":"10.1016/j.biocel.2015.08.003","title":"Antiproliferative and pro-apoptotic effects of three fungal exocellular β-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a","year":2015,"lang":"en","type":"article","venue":"The International Journal of Biochemistry & Cell Biology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Universidade de São Paulo; Lakehead University","keywords":"AMPK; Oxidative stress; Chemistry; Apoptosis; MCF-7; AMP-activated protein kinase; Transcription factor; Protein kinase A; Cancer research; Forkhead Transcription Factors; Kinase; Breast cancer; Cell biology; Biology; Internal medicine; Biochemistry; Cancer; Human breast; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002967054,0.0002150151,0.0002730115,0.00006609321,0.00003760185,0.00002809686,0.0003358749,0.0001858399,0.00001365178],"category_scores_gemma":[0.00007770723,0.0001387813,0.00007812723,0.00009536831,0.0003881231,0.000019966,0.00005808593,0.0002222374,6.250905e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006374474,"about_ca_system_score_gemma":0.0001436159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001885473,"about_ca_topic_score_gemma":0.00006484098,"domain_scores_codex":[0.9987146,0.0001639418,0.0004359543,0.0002563657,0.0002505185,0.0001785709],"domain_scores_gemma":[0.9988541,0.00006373864,0.0003850623,0.0001507402,0.0004364417,0.0001099241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002028767,0.0001176363,0.003489957,0.00004627172,0.0001870832,0.000002315263,0.0006308631,0.00003116045,0.9928383,0.000009286357,0.0001678745,0.0004504357],"study_design_scores_gemma":[0.003109823,0.0002401641,0.001844432,0.00009976639,0.00003713094,0.00002386474,0.0001383602,0.00008389497,0.9938348,0.00009926684,0.00034927,0.000139245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942681,0.001942222,0.0008157056,0.001837791,0.0001796554,0.00048098,0.0004562057,0.000003468143,0.00001585499],"genre_scores_gemma":[0.999192,0.0002562888,0.00008544439,0.0001426372,0.0001166128,0.00002665621,0.0001102698,0.00001505748,0.00005502122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004923895,"threshold_uncertainty_score":0.5659338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148579408428992,"score_gpt":0.2411307901357221,"score_spread":0.2296449960514321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}