{"id":"W1719416134","doi":"10.1016/j.biocel.2015.08.003","title":"Antiproliferative and pro-apoptotic effects of three fungal exocellular β-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a","year":2015,"lang":"en","type":"article","venue":"The International Journal of Biochemistry & Cell Biology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Universidade de São Paulo; Lakehead University","keywords":"AMPK; Oxidative stress; Chemistry; Apoptosis; MCF-7; AMP-activated protein kinase; Transcription factor; Protein kinase A; Cancer research; Forkhead Transcription Factors; Kinase; Breast cancer; Cell biology; Biology; Internal medicine; Biochemistry; Cancer; Human breast; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007592214,0.0002474081,0.0001356684,0.0001934565,0.0001619993,0.0001747102,0.00008651243,0.0001457976,0.0009123128],"category_scores_gemma":[0.00005118414,0.00008301691,0.0002189277,0.0001814942,0.0001348808,0.00009837162,0.0001166871,0.000338178,0.0001007908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881313,"about_ca_system_score_gemma":0.0002312759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009982511,"about_ca_topic_score_gemma":0.001655096,"domain_scores_codex":[0.9999393,0.000007243396,0.00000585424,0.000008442576,0.00001624642,0.00002293786],"domain_scores_gemma":[0.9999679,0.000003345914,0.000008797773,0.000003635712,0.000004945148,0.00001132668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007618251,0.00005523141,0.0004141777,0.0000389352,0.000007542377,0.00003148129,0.00001476759,0.00005175918,0.9966565,0.00008362281,0.00005160087,0.001832494],"study_design_scores_gemma":[0.00005912598,0.0006805807,0.0121022,0.000008009688,0.00002918892,0.0001044335,0.00006377356,0.0002885185,0.9848428,0.0000591244,0.001756834,0.000005369138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971486,0.001085792,0.0003349753,0.00009389657,0.00002582358,0.00001196423,0.0002926567,0.00002198332,0.0009843707],"genre_scores_gemma":[0.9979835,0.0007006769,0.0003131479,0.0000413102,0.000003575834,0.00001162761,0.0003154342,0.000002393469,0.0006282282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009982511,"threshold_uncertainty_score":0.003051996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148579408428992,"score_gpt":0.2411307901357221,"score_spread":0.2296449960514321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}