{"id":"W172096484","doi":"10.2741/1783","title":"Inhibition of thrombin: relevance to anti-thrombosis strategy","year":2006,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Heart and Stroke Foundation of Canada","keywords":"Discovery and development of direct thrombin inhibitors; Argatroban; Medicine; Thrombin; Ximelagatran; Hirudin; Pharmacology; Warfarin; Direct thrombin inhibitor; Bivalirudin; Unstable angina; Thrombosis; Coagulation; Myocardial infarction; Cardiology; Internal medicine; Dabigatran; Atrial fibrillation; Platelet; Percutaneous coronary intervention","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005941255,0.0006234597,0.003638745,0.001101926,0.0001006388,0.00004875764,0.0005120552,0.0005599235,0.0000362931],"category_scores_gemma":[0.0002347376,0.0005412958,0.0004581508,0.003395765,0.0004937733,0.000266617,0.000191809,0.0006077092,0.00006767869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005791027,"about_ca_system_score_gemma":0.0009013821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002307077,"about_ca_topic_score_gemma":0.00002772289,"domain_scores_codex":[0.9958581,0.0001572777,0.001348659,0.001193388,0.0006655463,0.0007770009],"domain_scores_gemma":[0.9980481,0.00007876085,0.0005140287,0.0009340952,0.0001358748,0.000289203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002502855,0.001459945,0.004817303,0.02694631,0.000242212,0.0001212125,0.0002800068,0.00001916568,0.006301567,0.0007382342,0.033437,0.925612],"study_design_scores_gemma":[0.001269573,0.001198977,0.0145957,0.05368411,0.001168244,0.0001155818,0.0001900398,0.00004883529,0.00402747,0.0005595836,0.9213236,0.001818271],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007708515,0.9809074,0.0009618208,0.0001161254,0.00190798,0.002580191,0.0001362906,0.00009524656,0.005586458],"genre_scores_gemma":[0.01186832,0.9791524,0.008256,0.0001011617,0.0001095596,0.00009557203,0.00008534388,0.00007216929,0.0002594915],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9237937,"threshold_uncertainty_score":0.9997039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06995395919596555,"score_gpt":0.3570344916102503,"score_spread":0.2870805324142848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}