{"id":"W172217614","doi":"10.1007/978-0-387-39975-1_10","title":"Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways","year":2007,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec","funders":"","keywords":"Cell biology; Protein kinase B; Heat shock protein; Signal transduction; MAPK/ERK pathway; Heat shock factor; Heat shock; Kinase; Downregulation and upregulation; Protein kinase A; Transient receptor potential channel; Biology; Chemistry; Receptor; Hsp70; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004941671,0.001302888,0.001596417,0.001232672,0.0003214381,0.001366165,0.001811402,0.001005278,0.002468706],"category_scores_gemma":[0.000345126,0.0002905215,0.0003809605,0.001519586,0.0009285746,0.001276912,0.0009205627,0.001938517,0.002171463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009232756,"about_ca_system_score_gemma":0.000935462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004942,"about_ca_topic_score_gemma":0.0006264974,"domain_scores_codex":[0.9998081,0.00002265293,0.00001827006,0.00003555056,0.00008333243,0.00003211826],"domain_scores_gemma":[0.9998389,0.0000580401,0.00003035638,0.000008334425,0.00004323528,0.00002104227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001954356,0.00008480873,0.0002529317,0.01118644,0.00009102858,0.0004928706,0.0001065064,0.001046086,0.02926711,0.02176736,0.02239258,0.9131169],"study_design_scores_gemma":[0.00002847377,0.00008640891,0.00142418,0.001491651,0.00007955603,0.00133723,0.0001063618,0.0002492546,0.008997657,0.01145161,0.9747141,0.00003345464],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003821686,0.99625,0.001053176,0.0002868623,0.0003134542,0.00001148848,0.00002980094,0.00002484942,0.001648123],"genre_scores_gemma":[0.001354951,0.9969633,0.0004640146,0.0001360804,0.000183134,0.00001636043,0.00004575966,0.000001496585,0.0008348142],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002468706,"threshold_uncertainty_score":0.008258641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.060186480206405,"score_gpt":0.4018315448674143,"score_spread":0.3416450646610094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}