{"id":"W1730021373","doi":"10.1007/s00059-011-3470-3","title":"Mechanisms and management of doxorubicin cardiotoxicity","year":2011,"lang":"en","type":"article","venue":"Herz","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; Prevention of Organ Failure; University Health Network; University of Toronto; Toronto General Hospital; Heart and Stroke Foundation; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Cardiotoxicity; Medicine; Doxorubicin; Dexrazoxane; Pharmacology; Neuregulin; Cancer research; Cancer; Chemotherapy; Internal medicine; Receptor; Anthracycline; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330542,0.00007527073,0.0001917988,0.00003895045,0.00002142139,0.000002300124,0.00002908803,0.00006095177,0.00008127066],"category_scores_gemma":[0.000002744853,0.00006816445,0.00006637249,0.00007693757,0.00003786218,0.00003161457,0.00002124625,0.00005909308,0.000006566263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002083944,"about_ca_system_score_gemma":0.000008941627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004207668,"about_ca_topic_score_gemma":0.000002555787,"domain_scores_codex":[0.9994853,0.00001525751,0.0001225148,0.0001373859,0.0001361419,0.0001034612],"domain_scores_gemma":[0.9996848,0.000005464151,0.00003670121,0.0001833345,0.00002829139,0.00006143712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000156491,0.000116872,0.0009720072,0.0004812666,0.0003376989,0.00005834306,0.001071327,4.10983e-7,0.9576954,0.01864287,0.0001671848,0.02030009],"study_design_scores_gemma":[0.0009228633,0.0001381664,0.04085201,0.0001218906,0.0001021715,0.00004099008,0.0003049646,0.0000117931,0.9550985,0.001940518,0.0003950787,0.00007111207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416903,0.000166037,0.003785222,0.00006608047,0.00006561723,0.0003628477,0.000002690023,0.00003901569,0.05382224],"genre_scores_gemma":[0.9911022,0.0002882029,0.007938246,0.0002111997,0.00002034731,0.00001076861,0.000002542282,0.00001103803,0.0004154418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0534068,"threshold_uncertainty_score":0.2779665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431171912315176,"score_gpt":0.247516230793602,"score_spread":0.2132045116704502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}