{"id":"W1730777739","doi":"10.5588/ijtld.14.0829","title":"Three months of weekly rifapentine plus isoniazid is less hepatotoxic than nine months of daily isoniazid for LTBI","year":2015,"lang":"en","type":"article","venue":"The International Journal of Tuberculosis and Lung Disease","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention Foundation; Sanofi","keywords":"Medicine; Isoniazid; Internal medicine; Rifapentine; Jaundice; Gastroenterology; Body mass index; Vomiting; Latent tuberculosis; Tuberculosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00144338,0.0002289738,0.0004404935,0.0002011157,0.0001320353,0.00003824594,0.0006354061,0.0001579687,0.0001577807],"category_scores_gemma":[0.0002638756,0.0001725002,0.0003491488,0.0001304893,0.0002033922,0.0002755242,0.0001407772,0.0004635532,0.000004047415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340029,"about_ca_system_score_gemma":0.0002915227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526013,"about_ca_topic_score_gemma":0.00008896973,"domain_scores_codex":[0.9979855,0.0001898768,0.0008054476,0.0002027982,0.0005724581,0.0002439573],"domain_scores_gemma":[0.9973636,0.0003389631,0.0008278158,0.0001924313,0.0009164268,0.0003608147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.05258717,0.006680422,0.5699074,0.001474609,0.01432752,0.000245887,0.0135127,0.01234492,0.102241,0.007837119,0.09528488,0.1235564],"study_design_scores_gemma":[0.03984933,0.002761768,0.1964192,0.001456012,0.007141054,0.0004085499,0.003360646,0.4001805,0.2689764,0.02446422,0.05316396,0.001818318],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835833,0.00335995,0.001217531,0.00896262,0.001497364,0.0005982114,0.0004478706,0.00001205124,0.0003211225],"genre_scores_gemma":[0.9975277,0.0005768415,0.0001511278,0.0008635276,0.0005862613,0.00003800566,0.00001525563,0.00002415524,0.0002171431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3878355,"threshold_uncertainty_score":0.7034354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09286789638970532,"score_gpt":0.3917793239375435,"score_spread":0.2989114275478382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}