{"id":"W1730777739","doi":"10.5588/ijtld.14.0829","title":"Three months of weekly rifapentine plus isoniazid is less hepatotoxic than nine months of daily isoniazid for LTBI","year":2015,"lang":"en","type":"article","venue":"The International Journal of Tuberculosis and Lung Disease","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention Foundation; Sanofi","keywords":"Medicine; Isoniazid; Internal medicine; Rifapentine; Jaundice; Gastroenterology; Body mass index; Vomiting; Latent tuberculosis; Tuberculosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001413286,0.000255985,0.0003748812,0.0002001739,0.0002566886,0.0004640483,0.0002095294,0.0005034241,0.003050013],"category_scores_gemma":[0.005096418,0.0001790044,0.000454437,0.000238902,0.0002786758,0.0003433971,0.0001853484,0.0003992797,0.000253783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216439,"about_ca_system_score_gemma":0.0003028538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009543087,"about_ca_topic_score_gemma":0.001925828,"domain_scores_codex":[0.9992877,0.0002863644,0.00009497786,0.0001389749,0.0001136879,0.00007849484],"domain_scores_gemma":[0.9956707,0.0007874715,0.002529825,0.0001621337,0.0001907099,0.0006591133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.008007294,0.0008088553,0.9669507,0.0001771013,0.0003011253,0.0002355996,0.0001230757,0.00009861706,0.003036554,0.00002813954,0.0004103853,0.01982251],"study_design_scores_gemma":[0.0002571234,0.004803291,0.9935841,0.00003350368,0.0001211362,0.0003956867,0.00008380039,0.0001426717,0.0002780941,0.00001845955,0.0002771434,0.000004979584],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983897,0.000898767,0.0001130242,0.0001446324,0.00002228958,0.00001594384,0.00006400408,0.000009285344,0.0003423875],"genre_scores_gemma":[0.999569,0.000114079,0.00008182686,0.00005665381,0.00001280896,0.000005209598,0.00005201554,0.000001338331,0.0001071485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003050013,"threshold_uncertainty_score":0.01020324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09286789638970532,"score_gpt":0.3917793239375435,"score_spread":0.2989114275478382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}