{"id":"W1731301142","doi":"10.1139/y2012-089","title":"Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats","year":2012,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Endocrinology; Endothelium; Internal medicine; Endothelial dysfunction; Medicine; Vascular smooth muscle; Losartan; Vasodilation; Pharmacology; Chemistry; Blood pressure; Angiotensin II","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000185048,0.0005618101,0.0007806523,0.0004760379,0.0002359083,0.0002920431,0.0003027669,0.0004446575,0.001469916],"category_scores_gemma":[0.0001518343,0.0002540844,0.000416398,0.0002456284,0.0002668391,0.0003311605,0.0002447428,0.001434408,0.0003353495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270579,"about_ca_system_score_gemma":0.0005077324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001543285,"about_ca_topic_score_gemma":0.003398605,"domain_scores_codex":[0.9998696,0.00001769082,0.0000171096,0.0000243207,0.00002558827,0.00004558489],"domain_scores_gemma":[0.9998184,0.000009452227,0.00004277803,0.00001589437,0.00002156554,0.00009189559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007104581,0.001859192,0.001267783,0.0002842755,0.00009900937,0.0003660202,0.00006418028,0.0001826914,0.9737404,0.0001688258,0.000492213,0.01437075],"study_design_scores_gemma":[0.001362472,0.03499115,0.0272155,0.00005510125,0.0004702219,0.0006404514,0.0002153003,0.001519336,0.9266747,0.0002121149,0.006595253,0.00004829655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885949,0.007391198,0.001081483,0.0004212008,0.000226458,0.00004795024,0.0004271546,0.0002241048,0.001585604],"genre_scores_gemma":[0.9852991,0.00756333,0.001841238,0.0004082749,0.0000915217,0.0001117568,0.0007262846,0.00002353598,0.003935059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543285,"threshold_uncertainty_score":0.004917324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00943874631337286,"score_gpt":0.2514781732744302,"score_spread":0.2420394269610573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}