{"id":"W1731605952","doi":"10.1002/pd.4597","title":"First trimester screening for Down syndrome using nuchal translucency, maternal serum pregnancy‐associated plasma protein A, free‐β human chorionic gonadotrophin, placental growth factor, and α‐fetoprotein","year":2015,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; North York General Hospital","funders":"","keywords":"Pregnancy-associated plasma protein A; Placental growth factor; Medicine; Nuchal translucency; Obstetrics; Down syndrome; Second trimester; Gestation; Pregnancy; First trimester; Gynecology; Nuchal Translucency Measurement; Alpha-fetoprotein; Andrology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001190134,0.0006030782,0.0003497952,0.0009287255,0.0001146769,0.0003389672,0.0002519056,0.0003361157,0.0007735651],"category_scores_gemma":[0.004432473,0.0002386311,0.0003591781,0.0003330256,0.0003011517,0.0002799639,0.0002721325,0.0002930469,0.0001167479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206007,"about_ca_system_score_gemma":0.0002282728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001818429,"about_ca_topic_score_gemma":0.00149351,"domain_scores_codex":[0.9990964,0.000308515,0.00007060795,0.0001982477,0.000260607,0.00006562926],"domain_scores_gemma":[0.9981177,0.0008114862,0.0006654456,0.0001084317,0.0001485276,0.0001484388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000273001,0.00003056695,0.9926124,0.0000189376,0.0000660384,0.0001669812,0.00003801203,0.00008746274,0.001798789,0.000008739249,0.00002614565,0.00487297],"study_design_scores_gemma":[0.00002112369,0.0009559802,0.9883069,0.00002288405,0.0001432497,0.005942612,0.00005552491,0.001374096,0.002987875,0.00002355973,0.0001594145,0.000006813712],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987875,0.000542005,0.0003772376,0.00002026991,0.000003198488,0.000004588619,0.00006814444,0.000008244561,0.0001888141],"genre_scores_gemma":[0.9992967,0.0001357218,0.0004232426,0.000006358227,0.000004574595,0.000002490164,0.00006291944,9.510514e-7,0.00006702922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818429,"threshold_uncertainty_score":0.006294131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04694880361140588,"score_gpt":0.2737734381666357,"score_spread":0.2268246345552299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}