{"id":"W1731605952","doi":"10.1002/pd.4597","title":"First trimester screening for Down syndrome using nuchal translucency, maternal serum pregnancy‐associated plasma protein A, free‐β human chorionic gonadotrophin, placental growth factor, and α‐fetoprotein","year":2015,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; North York General Hospital","funders":"","keywords":"Pregnancy-associated plasma protein A; Placental growth factor; Medicine; Nuchal translucency; Obstetrics; Down syndrome; Second trimester; Gestation; Pregnancy; First trimester; Gynecology; Nuchal Translucency Measurement; Alpha-fetoprotein; Andrology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002561159,0.0005877259,0.0007635102,0.000237835,0.0004102371,0.0001749094,0.0003793594,0.0003976998,0.0000936507],"category_scores_gemma":[0.0008943097,0.0005516093,0.0002569059,0.0002307694,0.0001785136,0.0005525331,0.0002876139,0.0004760232,0.00001222305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004316,"about_ca_system_score_gemma":0.0001417028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001803086,"about_ca_topic_score_gemma":0.0002254263,"domain_scores_codex":[0.9968181,0.0000986923,0.0006573527,0.0008095417,0.0006989522,0.0009173193],"domain_scores_gemma":[0.9980373,0.0002583775,0.0002706296,0.0004535753,0.0002182105,0.0007619528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002708405,0.002332423,0.9717106,0.003404666,0.00140923,0.002009804,0.002132116,0.0002716956,0.003173943,0.0006811972,0.001137775,0.009028126],"study_design_scores_gemma":[0.03906017,0.005833613,0.8386784,0.01915804,0.0009622657,0.001293905,0.0002134831,0.009679973,0.08116078,0.001476058,0.0003250853,0.002158197],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991399,0.00161643,0.0008126571,0.0005710938,0.0002362691,0.002985746,0.001985477,0.000284078,0.0001091961],"genre_scores_gemma":[0.9936193,0.00006703888,0.004686826,0.00006089446,0.0001546394,0.0007736138,0.0002753948,0.0001218373,0.0002404833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1330322,"threshold_uncertainty_score":0.9996935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04694880361140588,"score_gpt":0.2737734381666357,"score_spread":0.2268246345552299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}