{"id":"W1736408509","doi":"10.1002/bmc.3199","title":"<i>In vitro</i> ketamine CYP3A‐mediated metabolism study using mammalian liver S9 fractions, cDNA expressed enzymes and liquid chromatography tandem mass spectrometry","year":2014,"lang":"en","type":"article","venue":"Biomedical Chromatography","topic":"Treatment of Major Depression","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep de Saint Hyacinthe","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Chromatography; S9 fraction; CYP3A; Formic acid; Selected reaction monitoring; Mass spectrometry; Tandem mass spectrometry; Ketamine; Midazolam; Isotope dilution; Cytochrome P450; Metabolism; Enzyme; Biochemistry; Microsome; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004004969,0.0005206498,0.0003494338,0.0002370268,0.0002158057,0.0003644629,0.000236805,0.0002618975,0.0006460696],"category_scores_gemma":[0.0003109995,0.0001776664,0.0005410925,0.0003097987,0.0002217003,0.0002592962,0.0001320951,0.0003953518,0.0007909446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236617,"about_ca_system_score_gemma":0.0003089766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008392336,"about_ca_topic_score_gemma":0.001026999,"domain_scores_codex":[0.9996663,0.00008581313,0.00004408662,0.00009899079,0.00007377785,0.00003104684],"domain_scores_gemma":[0.9998285,0.00003635235,0.0000567168,0.0000243223,0.00004472012,0.000009453485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001233136,0.00002367935,0.0003332644,0.00004712561,0.0000104754,0.00004343001,0.00001296472,0.0001129005,0.9978816,0.00006642013,0.00005615782,0.001288562],"study_design_scores_gemma":[0.000007181879,0.000195631,0.002092176,0.000003433563,0.00002212675,0.0002415288,0.00001045346,0.0009516283,0.9948795,0.00003177915,0.001559358,0.000005114759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9013191,0.005182592,0.0855047,0.0002976925,0.0001040507,0.0002365988,0.003617132,0.0007166068,0.003021529],"genre_scores_gemma":[0.8815619,0.005093561,0.09435605,0.0003287993,0.0001025087,0.0004257979,0.01184085,0.0002486461,0.006041924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008392336,"threshold_uncertainty_score":0.002348363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220499706074079,"score_gpt":0.2576558082010746,"score_spread":0.2454508111403338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}