{"id":"W1738288880","doi":"10.1111/bph.12705","title":"Identifying ligand‐specific signalling within biased responses: focus on δ opioid receptor ligands","year":2014,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Functional selectivity; G protein-coupled receptor; Opioid receptor; Confounding; Signalling; Opioid; Neuroscience; Computational biology; Analgesic; Focus (optics); Bioinformatics; Receptor; Medicine; Pharmacology; Computer science; Psychology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001056,0.0008261203,0.001494014,0.001873363,0.0002540571,0.001112421,0.001004949,0.001307232,0.002417024],"category_scores_gemma":[0.001269527,0.0003521253,0.0007029015,0.001774707,0.0008898685,0.00180225,0.000705843,0.002118008,0.001638641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008140947,"about_ca_system_score_gemma":0.0009604659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007455617,"about_ca_topic_score_gemma":0.001121401,"domain_scores_codex":[0.9996737,0.00007102456,0.00003585362,0.00006536429,0.0001240982,0.00002996347],"domain_scores_gemma":[0.999059,0.0005752899,0.0001085685,0.00003007459,0.0001889093,0.00003811891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001273769,0.0000600647,0.0003239234,0.02284098,0.0001350218,0.0002468773,0.00009419974,0.0007087787,0.005705469,0.01290785,0.01198895,0.9448605],"study_design_scores_gemma":[0.00003000055,0.0002468365,0.002518839,0.008240213,0.0003377116,0.00285926,0.0001481235,0.000517836,0.005173457,0.009054428,0.9708044,0.00006890207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000211272,0.9979916,0.0005564369,0.0003382807,0.0001437878,0.000004530578,0.00001253689,0.000009230602,0.0007324382],"genre_scores_gemma":[0.001604427,0.9967828,0.0005567085,0.0003110477,0.0001413298,0.00000873561,0.00001934948,0.000003721723,0.0005718176],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002417024,"threshold_uncertainty_score":0.008085787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0430549689960044,"score_gpt":0.3380518136131773,"score_spread":0.2949968446171728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}