{"id":"W1738847488","doi":"10.1046/j.1365-2125.2000.00257.x","title":"A double‐blind, placebo‐controlled study to assess tolerability, pharmacokinetics and preliminary pharmacodynamics of single escalating doses of Z13752A, a novel dual inhibitor of the metalloproteases ACE and NEP, in healthy volunteers","year":2000,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"ASTER","funders":"","keywords":"Tolerability; Medicine; Placebo; Pharmacokinetics; Pharmacodynamics; Volunteer; Adverse effect; Oral administration; Supine position; Pharmacology; Cmax; Internal medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001555355,0.001130493,0.002410991,0.0003193534,0.0005549248,0.0004346233,0.0006329978,0.001346139,0.004331453],"category_scores_gemma":[0.001100399,0.0006642412,0.0006895416,0.0002526098,0.001147357,0.0006778245,0.0002886945,0.00153308,0.0008204859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002536899,"about_ca_system_score_gemma":0.0007808227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003281113,"about_ca_topic_score_gemma":0.0006422848,"domain_scores_codex":[0.9994024,0.0002349631,0.00005538109,0.0001586662,0.00007394247,0.00007457061],"domain_scores_gemma":[0.999155,0.0001808042,0.0001676613,0.0001072341,0.00009307722,0.0002962344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8651845,0.03653219,0.001261912,0.000531643,0.0004414795,0.000060609,0.00008797532,0.0002423056,0.0717549,0.0000893017,0.0004832413,0.02332995],"study_design_scores_gemma":[0.5227691,0.4657791,0.005800769,0.00001497902,0.0002733884,0.00006712038,0.00002145841,0.0003666752,0.004063773,0.00007341732,0.000749087,0.0000211867],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926696,0.001336219,0.001283816,0.0001538892,0.0002304559,0.003205224,0.0004099495,0.00008858182,0.0006222897],"genre_scores_gemma":[0.9849226,0.00115252,0.003942353,0.0008116906,0.0004479303,0.004939386,0.0007219373,0.00002552703,0.003036003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004331453,"threshold_uncertainty_score":0.01449013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05841792022268694,"score_gpt":0.3808963554784602,"score_spread":0.3224784352557733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}