{"id":"W1740564681","doi":"10.1016/j.celrep.2015.05.045","title":"Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health; Alberta Innovates; Alberta Innovates - Health Solutions; Universitair Medisch Centrum Groningen; National Institute of Allergy and Infectious Diseases; European Commission; Crohn's and Colitis Foundation; Wellcome Trust; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America","keywords":"Autophagy; ATG16L1; Ubiquitin ligase; Biology; Ubiquitin; Allele; Functional genomics; Cell biology; Genetics; Genomics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002480419,0.0001061063,0.0001425735,0.00004227957,0.00001569864,0.00001679961,0.00006710516,0.00007796752,0.000004888021],"category_scores_gemma":[0.0001915835,0.0001057685,0.00007226138,0.00004848763,0.00002560675,0.000002685135,0.00005454162,0.00004236169,6.329008e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001686342,"about_ca_system_score_gemma":0.0001878373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009305789,"about_ca_topic_score_gemma":0.00004318885,"domain_scores_codex":[0.9991838,0.00001887146,0.0003196505,0.000255304,0.00006417792,0.0001582086],"domain_scores_gemma":[0.9993607,0.000005928053,0.0001344297,0.0003042555,0.00008620624,0.0001084501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002616656,0.0000937365,0.003953936,0.00004987064,0.00002080081,0.0001798707,0.000168274,0.002816488,0.9910122,0.000003697405,0.0006073576,0.000832166],"study_design_scores_gemma":[0.0006135523,0.00009287595,0.03018244,0.00001441418,0.00004079839,0.00002862112,0.0001237683,0.001283148,0.9506769,0.000334248,0.01642363,0.0001855962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899905,0.000943806,0.008102099,0.000004330625,0.0004973133,0.0002288221,0.00003503393,0.000008027947,0.0001900041],"genre_scores_gemma":[0.9980723,0.00007601396,0.001164502,0.000007576119,0.000123545,0.00002005974,0.0001570478,0.00001936399,0.0003595383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04033522,"threshold_uncertainty_score":0.4313114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007277653453890835,"score_gpt":0.2539880478541198,"score_spread":0.2467103944002289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}