{"id":"W1743462958","doi":"10.1016/j.celrep.2015.07.011","title":"Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Biology; Kinase; Effector; MAPK/ERK pathway; Cell biology; Mitogen-activated protein kinase; Embryonic stem cell; MAPK7; Signal transduction; Embryo; Embryogenesis; Genetics; MAP kinase kinase kinase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002860836,0.0004913332,0.0002864335,0.000511804,0.0001123079,0.0003940105,0.0003752319,0.000238675,0.0006293565],"category_scores_gemma":[0.000192775,0.0002709177,0.0002592887,0.00015213,0.0002706732,0.0003315263,0.000281065,0.0003487552,0.0003116885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296972,"about_ca_system_score_gemma":0.0001825493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001466445,"about_ca_topic_score_gemma":0.0002546201,"domain_scores_codex":[0.9996899,0.0000565044,0.00003253357,0.00007019048,0.00007916029,0.00007169578],"domain_scores_gemma":[0.9997382,0.00003811289,0.00008987646,0.00004341163,0.00002924087,0.00006123492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007796024,0.00000625586,0.0005503514,0.00002372701,0.000004652939,0.0001179662,0.00001074083,0.0000746614,0.9978564,0.0002751929,0.00001294253,0.0009891739],"study_design_scores_gemma":[0.00001417111,0.0001796634,0.03148032,0.00001122634,0.00004687608,0.002222634,0.00004909148,0.001399154,0.9619946,0.0002783052,0.002307881,0.00001602879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951705,0.001335584,0.002182386,0.00004750815,0.00000816972,0.00000717252,0.0001786906,0.00005494364,0.001014971],"genre_scores_gemma":[0.9963892,0.0005360554,0.001689494,0.000024473,0.000005196796,0.00001079646,0.0002393744,0.00001878505,0.001086751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006293565,"threshold_uncertainty_score":0.002105415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734037690953149,"score_gpt":0.2055668586401551,"score_spread":0.1882264817306236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}