{"id":"W1743462958","doi":"10.1016/j.celrep.2015.07.011","title":"Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Biology; Kinase; Effector; MAPK/ERK pathway; Cell biology; Mitogen-activated protein kinase; Embryonic stem cell; MAPK7; Signal transduction; Embryo; Embryogenesis; Genetics; MAP kinase kinase kinase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089278,0.00007460498,0.00008218461,0.00002047129,0.00003250582,0.000005695178,0.00002415545,0.00005839918,0.00001510181],"category_scores_gemma":[0.00003250127,0.00007017729,0.00002262739,0.00001904917,0.00003012204,0.000001934801,0.00007181701,0.00002578429,0.000002710485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007617707,"about_ca_system_score_gemma":0.0001457257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000508212,"about_ca_topic_score_gemma":0.000003926721,"domain_scores_codex":[0.9993895,0.000009735731,0.0001948101,0.0002024778,0.000100939,0.0001024895],"domain_scores_gemma":[0.9995639,0.000002059587,0.0001060411,0.0001743496,0.00006526053,0.00008839837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004044081,0.00005629054,0.03069154,0.00008320658,0.00001741233,0.000138504,0.00007555016,0.00001149178,0.9636169,0.00001439625,0.004674338,0.0005798972],"study_design_scores_gemma":[0.0001871427,0.00005932051,0.02986542,0.00001063608,0.000005803216,0.0001961588,0.00003877636,4.953729e-7,0.9065706,0.00005115187,0.06292652,0.00008799269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912773,0.001184841,0.0001170763,0.000009426294,0.0002883396,0.00006193691,0.000001081255,0.000006195057,0.00705376],"genre_scores_gemma":[0.9942241,0.00001465265,0.0007315743,0.00001303171,0.0001008269,0.000007713231,0.00005910068,0.000008345438,0.0048406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05825219,"threshold_uncertainty_score":0.2861747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734037690953149,"score_gpt":0.2055668586401551,"score_spread":0.1882264817306236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}