{"id":"W174443042","doi":"10.1182/blood.v122.21.3636.3636","title":"A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal Of Rivaroxaban-Induced Anticoagulation In Healthy Subjects By Andexanet Alfa (PRT064445), An Antidote For Fxa Inhibitors","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"","keywords":"Rivaroxaban; Medicine; Placebo; Pharmacokinetics; Pharmacodynamics; Antidote; Pharmacology; Cohort; Anesthesia; Clinical trial; Randomized controlled trial; Anticoagulant; Internal medicine; Urology; Warfarin; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00156468,0.0002681864,0.001484431,0.0003490831,0.000094955,0.00005257607,0.00008395893,0.0002013844,0.00005943537],"category_scores_gemma":[0.0006135269,0.0002233475,0.0003446111,0.0003081413,0.00005648717,0.0003861411,0.00002346812,0.0001479414,0.000006059603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002853552,"about_ca_system_score_gemma":0.000134071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003151944,"about_ca_topic_score_gemma":0.00003733448,"domain_scores_codex":[0.99728,0.0002784516,0.001317666,0.0003832192,0.0003744647,0.0003661849],"domain_scores_gemma":[0.998044,0.0007396676,0.0006511785,0.0002588956,0.0001437929,0.0001625103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9687551,0.0006079269,0.003956965,0.0001164367,0.0002749813,0.000002806653,0.0001858452,0.00001247548,0.02503307,0.0001132217,0.0001371765,0.0008040014],"study_design_scores_gemma":[0.9809719,0.002728903,0.00009664799,0.0000728141,0.0007581738,0.000003460249,0.000132763,0.004570147,0.01032672,0.00009421551,0.00003743973,0.0002068063],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793466,0.0001191639,0.0003746779,0.000868688,0.0003552034,0.01851301,0.000009832231,0.00006524051,0.000347591],"genre_scores_gemma":[0.9970102,0.00002400619,0.001328482,0.0000833055,0.0009180926,0.000227052,0.0002479241,0.00003390903,0.0001270582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01828596,"threshold_uncertainty_score":0.9107848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05869333450192348,"score_gpt":0.3568677968344952,"score_spread":0.2981744623325717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}