{"id":"W174443042","doi":"10.1182/blood.v122.21.3636.3636","title":"A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal Of Rivaroxaban-Induced Anticoagulation In Healthy Subjects By Andexanet Alfa (PRT064445), An Antidote For Fxa Inhibitors","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"","keywords":"Rivaroxaban; Medicine; Placebo; Pharmacokinetics; Pharmacodynamics; Antidote; Pharmacology; Cohort; Anesthesia; Clinical trial; Randomized controlled trial; Anticoagulant; Internal medicine; Urology; Warfarin; Toxicity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004533986,0.002548783,0.003801089,0.0006109605,0.0007372989,0.001528413,0.001117879,0.002933815,0.008526527],"category_scores_gemma":[0.003646862,0.00104027,0.002116974,0.00046471,0.001622729,0.001756861,0.0005155393,0.003390502,0.00175454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005996841,"about_ca_system_score_gemma":0.002018204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005757583,"about_ca_topic_score_gemma":0.001054468,"domain_scores_codex":[0.9983037,0.0009138552,0.0001065235,0.0003456218,0.0001180033,0.0002123245],"domain_scores_gemma":[0.9979962,0.0005053565,0.0004350234,0.0002015271,0.0002362109,0.0006256916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9775274,0.01044822,0.0002670842,0.0003872487,0.0004870206,0.00003468608,0.00003212562,0.00009547844,0.003486184,0.00006983541,0.000771181,0.006393465],"study_design_scores_gemma":[0.9417125,0.05688429,0.0005372777,0.00001234684,0.0001527292,0.00001546086,0.000006307888,0.0001235743,0.0002002366,0.00006470491,0.0002833843,0.000007214071],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598108,0.005846304,0.002413607,0.001561594,0.001933005,0.02151551,0.002802575,0.0004282845,0.00368827],"genre_scores_gemma":[0.9515692,0.004271208,0.006062768,0.003281032,0.001692466,0.02377539,0.002993785,0.00007971703,0.006274376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008526527,"threshold_uncertainty_score":0.0285241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05869333450192348,"score_gpt":0.3568677968344952,"score_spread":0.2981744623325717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}