{"id":"W1744607539","doi":"10.1182/blood-2015-01-620377","title":"Sirolimus plus prednisone for Erdheim-Chester disease: an open-label trial","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Workers Compensation Board of British Columbia","funders":"","keywords":"Erdheim–Chester disease; Prednisone; Sirolimus; Medicine; Histiocyte; PI3K/AKT/mTOR pathway; Histiocytosis; Internal medicine; Disease; Pathology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280421,0.0001484478,0.0002995036,0.00003550392,0.000067655,0.00005848605,0.0001506597,0.00006266221,0.00003202902],"category_scores_gemma":[0.000149662,0.0001200118,0.00004034471,0.00006572144,0.00003779484,0.0001384845,0.00005916525,0.00004829088,0.00006312925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005443092,"about_ca_system_score_gemma":0.0004899297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004202509,"about_ca_topic_score_gemma":0.00001321987,"domain_scores_codex":[0.9990315,0.00002391612,0.0001936929,0.0003013191,0.0002080062,0.0002415848],"domain_scores_gemma":[0.9988911,0.00002667988,0.0000553464,0.0003998567,0.00008696177,0.0005400539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6653758,0.1843148,0.01228136,0.0008252965,0.004139196,0.001718174,0.005337884,0.00002565431,0.000549058,0.004727819,0.05956629,0.06113874],"study_design_scores_gemma":[0.9367578,0.00951827,0.001242011,0.00006979235,0.002177755,0.00002440362,0.0001359719,0.0005682867,0.0001131945,0.001470756,0.04764421,0.0002775229],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882873,0.0009116801,0.0001698021,0.000610261,0.0003250228,0.003149548,0.0001155128,0.00007960061,0.006351281],"genre_scores_gemma":[0.9870098,0.00001124373,0.002839371,0.0004510035,0.0004037291,0.0005359467,0.0003117205,0.00004924687,0.008387923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2713821,"threshold_uncertainty_score":0.489394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1382107749685668,"score_gpt":0.3699909789274466,"score_spread":0.2317802039588798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}