{"id":"W1747642895","doi":"10.1128/iai.00415-15","title":"Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection","year":2015,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Carleton University; Ste. Anne's Hospital","funders":"National Cancer Institute","keywords":"Biology; CD74; Antigen presentation; Major histocompatibility complex; Antigen processing; Antigen; Immunology; MHC class II; MHC class I; Toxoplasma gondii; Virology; T cell; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009600724,0.0003286212,0.0002232924,0.0001525819,0.0001285627,0.0002612379,0.000181282,0.0003241205,0.001029033],"category_scores_gemma":[0.000091575,0.0001216192,0.0001732873,0.0001229207,0.000299338,0.0001935894,0.0001863094,0.0006070432,0.0002556498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002719596,"about_ca_system_score_gemma":0.0001771258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003641366,"about_ca_topic_score_gemma":0.0005838829,"domain_scores_codex":[0.9998233,0.00002882807,0.00001698842,0.00003291886,0.00003998737,0.00005801407],"domain_scores_gemma":[0.9998615,0.00002178777,0.00003774609,0.00001047254,0.000008899461,0.0000595759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013439,0.00002566797,0.00007073176,0.0000141621,0.000001928353,0.00004184923,0.00000853566,0.00002502993,0.9993747,0.0000434112,0.00000972246,0.0002499081],"study_design_scores_gemma":[0.00003787166,0.0006159022,0.003264967,0.000004899468,0.00001878282,0.0001949469,0.00003851309,0.000620953,0.9936936,0.00003400967,0.001469646,0.000005695539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998356,0.000255524,0.000503069,0.00003544037,0.00002154439,0.00001537255,0.0001215029,0.00002659147,0.0006649729],"genre_scores_gemma":[0.9971008,0.0002492161,0.0006884903,0.00004948807,0.000009603496,0.00002234882,0.0001891758,0.00002168983,0.001669248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029033,"threshold_uncertainty_score":0.003442526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03371188477807991,"score_gpt":0.2839502442768183,"score_spread":0.2502383594987383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}