{"id":"W1748017913","doi":"10.1002/dta.1863","title":"Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements","year":2015,"lang":"en","type":"article","venue":"Drug Testing and Analysis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"World Anti-Doping Agency","keywords":"CYP3A4; Pharmacology; CYP2D6; Chemistry; Enzyme; Cytochrome P450; CYP1A2; Drug; Dietary supplement; In vivo; Biochemistry; Medicine; Biology; Food science; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282619,0.0003088365,0.0003754348,0.0002327084,0.000134958,0.00016323,0.0001661577,0.0002982848,0.001087275],"category_scores_gemma":[0.0002801674,0.0001641981,0.0003648164,0.0002670697,0.0001685254,0.0001147351,0.0001631002,0.0003901381,0.0002420001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866752,"about_ca_system_score_gemma":0.0001693686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006565095,"about_ca_topic_score_gemma":0.002047751,"domain_scores_codex":[0.999702,0.0001041717,0.00003463553,0.00005982138,0.00007485657,0.00002438165],"domain_scores_gemma":[0.9998701,0.00003761209,0.00004111013,0.0000133524,0.00002262693,0.00001517473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003040939,0.00006156063,0.0004821319,0.0001311437,0.00002451786,0.0000479054,0.00001559038,0.0000724308,0.9953855,0.00001864665,0.00003800226,0.003418377],"study_design_scores_gemma":[0.00003184538,0.001516292,0.004821293,0.00001106567,0.00003440552,0.0001602326,0.00002137602,0.0003266435,0.9910678,0.00001075673,0.001993844,0.000004373304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864678,0.008346751,0.002968247,0.00009915628,0.00003548646,0.0000722109,0.0003686285,0.00004996029,0.001591713],"genre_scores_gemma":[0.9892407,0.00368028,0.004336086,0.00005524899,0.00001934521,0.00006298468,0.0006162483,0.00001190626,0.0019772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087275,"threshold_uncertainty_score":0.003637314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1373796817628619,"score_gpt":0.4142317591891828,"score_spread":0.2768520774263209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}