{"id":"W1748137726","doi":"10.1200/jco.2014.32.18_suppl.lba4","title":"First results from the phase III ALTTO trial (BIG 2-06; NCCTG [Alliance] N063D) comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T→L), or their combination (T+L) in the adjuvant treatment of HER2-positive early breast cancer (EBC).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Lapatinib; Trastuzumab; Internal medicine; Hazard ratio; Regimen; Clinical endpoint; Oncology; Anthracycline; Gastroenterology; Breast cancer; Cancer; Confidence interval; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005764296,0.0003415603,0.002863874,0.0001126019,0.0001104467,0.00002532268,0.0006652891,0.0003357883,0.00009393477],"category_scores_gemma":[0.0009352971,0.0001530092,0.000416298,0.0004797167,0.0009274644,0.0001282448,0.00005106067,0.001174489,0.000004000568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005254853,"about_ca_system_score_gemma":0.002384135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006246898,"about_ca_topic_score_gemma":0.006474436,"domain_scores_codex":[0.9926824,0.002188846,0.003195503,0.0004321644,0.00104736,0.000453732],"domain_scores_gemma":[0.9853062,0.01004179,0.002880004,0.0006511282,0.0008785874,0.0002422792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6169071,0.02544352,0.04838683,0.0000510646,0.001898092,0.000205634,0.0140387,0.0002331618,0.001668385,0.0000519421,0.0006179856,0.2904977],"study_design_scores_gemma":[0.3576849,0.09250093,0.5382621,0.001413485,0.0003366209,0.0001018673,0.001722578,0.0008287623,0.00236531,0.0001607655,0.004406388,0.000216282],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810945,0.0006906638,0.0001052333,0.01535956,0.0004278467,0.001708375,0.0003189132,0.000009027753,0.0002859047],"genre_scores_gemma":[0.9906993,0.006795146,0.000369745,0.0005518329,0.001404211,0.00006368158,0.00003356285,0.00004004041,0.00004249562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4898753,"threshold_uncertainty_score":0.9443483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.276720956961872,"score_gpt":0.4792496435740614,"score_spread":0.2025286866121894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}