{"id":"W1748137726","doi":"10.1200/jco.2014.32.18_suppl.lba4","title":"First results from the phase III ALTTO trial (BIG 2-06; NCCTG [Alliance] N063D) comparing one year of anti-HER2 therapy with lapatinib alone (L), trastuzumab alone (T), their sequence (T→L), or their combination (T+L) in the adjuvant treatment of HER2-positive early breast cancer (EBC).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Lapatinib; Trastuzumab; Internal medicine; Hazard ratio; Regimen; Clinical endpoint; Oncology; Anthracycline; Gastroenterology; Breast cancer; Cancer; Confidence interval; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004677469,0.001343443,0.001986733,0.0003379775,0.0004357753,0.001196327,0.001041468,0.001665555,0.00717229],"category_scores_gemma":[0.004890647,0.0004172987,0.002667968,0.0004674374,0.0008084417,0.001049691,0.0006670614,0.003819592,0.001310747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0011809,"about_ca_system_score_gemma":0.001617914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001389466,"about_ca_topic_score_gemma":0.005112308,"domain_scores_codex":[0.9984649,0.001160718,0.00004478098,0.0001246881,0.0001112314,0.0000935764],"domain_scores_gemma":[0.9973315,0.0009092894,0.0006047076,0.0002214994,0.0001434263,0.0007896849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8530666,0.007058635,0.003114435,0.002565056,0.004132418,0.0001074621,0.0001729511,0.002979862,0.0027858,0.0005833608,0.03930285,0.08413065],"study_design_scores_gemma":[0.875173,0.0937442,0.008842706,0.0003525657,0.00282058,0.0002669586,0.00005306359,0.0009285791,0.0008404075,0.0007838657,0.01613175,0.00006232702],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.83415,0.0638864,0.005001289,0.01437063,0.00307886,0.008859541,0.03880908,0.0007165485,0.03112783],"genre_scores_gemma":[0.8786948,0.01686319,0.01020214,0.01840118,0.001915794,0.01042388,0.04673278,0.0002585175,0.01650777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00717229,"threshold_uncertainty_score":0.02473712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.276720956961872,"score_gpt":0.4792496435740614,"score_spread":0.2025286866121894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}