{"id":"W1749119508","doi":"10.1124/dmd.105.006197","title":"THE ROLE OF PREGNANE X RECEPTOR IN 2-ACETYLAMINOFLUORENE-MEDIATED INDUCTION OF DRUG TRANSPORT AND -METABOLIZING ENZYMES IN MICE","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Pregnane X receptor; 2-Acetylaminofluorene; Drug metabolism; Chemistry; Enzyme; Enzyme inducer; Drug; Pharmacology; Receptor; Nuclear receptor; Biology; Biochemistry; Microsome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141498,0.0001530941,0.000412551,0.0002011079,0.00005024624,0.000006307386,0.00005313294,0.00008110391,0.00000816144],"category_scores_gemma":[0.00001266131,0.0001122882,0.00005464484,0.0003014832,0.000128973,0.0002051341,0.000007976052,0.0001539662,6.098489e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001324908,"about_ca_system_score_gemma":0.00003670429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002651014,"about_ca_topic_score_gemma":0.0005446565,"domain_scores_codex":[0.9988081,0.00005907032,0.0004949415,0.0002241503,0.000216003,0.0001977658],"domain_scores_gemma":[0.9995651,0.000047309,0.0001387197,0.0001246537,0.00005500846,0.0000692082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00118291,0.0004251575,0.03427168,0.0003070936,0.00004742402,0.000004370268,0.009909654,0.00002035964,0.8819096,0.01124239,0.00001201351,0.06066732],"study_design_scores_gemma":[0.002557165,0.0000232324,0.3926548,0.0003518814,0.0001433567,0.000005782256,0.003472689,0.0001196879,0.597662,0.0003284879,0.002535033,0.0001459407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449477,0.05393568,0.00001915784,0.0004018496,0.00009908297,0.0003494496,0.00003710867,0.00001348488,0.0001964493],"genre_scores_gemma":[0.990817,0.008293172,0.0005016024,0.00002465455,0.00007916556,0.00002610543,0.000120591,0.0000148864,0.0001227884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3583831,"threshold_uncertainty_score":0.457898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003676878348612283,"score_gpt":0.2046489056279873,"score_spread":0.200972027279375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}