{"id":"W1749119508","doi":"10.1124/dmd.105.006197","title":"THE ROLE OF PREGNANE X RECEPTOR IN 2-ACETYLAMINOFLUORENE-MEDIATED INDUCTION OF DRUG TRANSPORT AND -METABOLIZING ENZYMES IN MICE","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Pregnane X receptor; 2-Acetylaminofluorene; Drug metabolism; Chemistry; Enzyme; Enzyme inducer; Drug; Pharmacology; Receptor; Nuclear receptor; Biology; Biochemistry; Microsome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006988485,0.001207606,0.0006300056,0.002518828,0.0005098141,0.0009921588,0.0007912404,0.001377977,0.002658814],"category_scores_gemma":[0.0003800644,0.00091022,0.001176464,0.0003849932,0.001387711,0.001090204,0.0004376743,0.002278249,0.0007800813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001001972,"about_ca_system_score_gemma":0.0005896206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360235,"about_ca_topic_score_gemma":0.001597029,"domain_scores_codex":[0.9991546,0.0002211413,0.00006394599,0.0001917393,0.0001587587,0.0002097793],"domain_scores_gemma":[0.9990705,0.0001363222,0.0003747902,0.0001819127,0.0000421713,0.0001943787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001824836,0.000243616,0.0006161182,0.00003236318,0.00002545782,0.0003111354,0.00004817794,0.0001658808,0.9937782,0.001045192,0.00008369495,0.001825254],"study_design_scores_gemma":[0.0002127799,0.001288479,0.004782699,0.00002075035,0.00008553414,0.0009044163,0.00008987998,0.001107785,0.9884651,0.0003962118,0.002622288,0.00002402235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867796,0.002508068,0.005901152,0.0007246026,0.00009031203,0.0001044386,0.001225058,0.0004675991,0.002199158],"genre_scores_gemma":[0.9815897,0.001613109,0.004372365,0.0002723002,0.00004568351,0.0001975587,0.0009601592,0.0002017359,0.01074739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002658814,"threshold_uncertainty_score":0.008894622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003676878348612283,"score_gpt":0.2046489056279873,"score_spread":0.200972027279375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}