{"id":"W1751510803","doi":"10.1038/nmeth.3580","title":"Cas9 gRNA engineering for genome editing, activation and repression","year":2015,"lang":"en","type":"article","venue":"Nature Methods","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":356,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Human Genome Research Institute; University of California, San Diego; National Cancer Institute; National Institutes of Health; Broad Institute; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; U.S. Department of Energy","keywords":"Guide RNA; Cas9; CRISPR; Genome editing; Nuclease; Computational biology; RNA editing; Biology; Psychological repression; RNA; Genome engineering; Genome; Genetics; Cell biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595869249530691,"score_gpt":0.4075014387992125,"score_spread":0.3915427463039056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}