{"id":"W1754241820","doi":"10.1111/bpa.12023","title":"Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant <scp>H</scp>istone 3 Tail","year":2013,"lang":"en","type":"review","venue":"Brain Pathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Deutsche Krebshilfe; Genome Canada; Cancer Research Institute","keywords":"Chromatin; Chromatin remodeling; Cancer research; Histone; Mutation; Biology; Somatic cell; Glioma; Germline mutation; Cancer; Isocitrate dehydrogenase; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000403445,0.0005431281,0.002598944,0.0008623027,0.00004477116,0.00001549738,0.0001376772,0.0006592344,0.00001516078],"category_scores_gemma":[0.001743185,0.0004296822,0.0003402807,0.0006239405,0.0001131589,0.00005116322,0.0001584387,0.0004281791,0.0000757726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310732,"about_ca_system_score_gemma":0.0002580786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001124921,"about_ca_topic_score_gemma":0.0001199824,"domain_scores_codex":[0.9971391,0.0003438102,0.001027883,0.000746161,0.0002278791,0.0005151754],"domain_scores_gemma":[0.9975915,0.0009363662,0.0006335567,0.0005236535,0.0001333096,0.0001816364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005090582,0.004437768,0.007568898,0.1213305,0.0006346912,0.03151874,0.003938232,0.000008697832,0.0006271382,0.001329478,0.01240888,0.8161461],"study_design_scores_gemma":[0.06280508,0.01996783,0.03866089,0.1312716,0.03816429,0.2406749,0.002351137,0.002048685,0.0004765982,0.002372698,0.4568008,0.004405415],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1879171,0.8098403,0.000022184,0.00004628296,0.0001599644,0.00148353,0.00003832177,0.00003846924,0.000453862],"genre_scores_gemma":[0.01072453,0.986408,0.001587028,0.00009156104,0.0001938432,0.0006316998,0.00008788928,0.0000910404,0.000184408],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8117406,"threshold_uncertainty_score":0.9998155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791892834449402,"score_gpt":0.282561130408569,"score_spread":0.2646422020640749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}