{"id":"W1757118677","doi":"10.1016/j.cjca.2015.10.005","title":"Screening Children for Familial Aortopathies: Tread With Caution","year":2015,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Children's Hospital of Eastern Ontario","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Medicine; Proband; Family history; Etiology; Asymptomatic; Genetic testing; Context (archaeology); Disease; Pediatrics; Penetrance; Genetic counseling; Mutation; Surgery; Pathology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000639481,0.0002702877,0.001220944,0.0003378267,0.0000903879,0.00002215888,0.0003815008,0.0004499502,0.000003430426],"category_scores_gemma":[0.0003719929,0.0002158261,0.0005011301,0.0001264835,0.0002055173,0.000004056811,0.0000250713,0.0003283427,0.000002408038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282993,"about_ca_system_score_gemma":0.00526913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004682262,"about_ca_topic_score_gemma":0.002841552,"domain_scores_codex":[0.9984794,0.0002870501,0.0003859982,0.0002858639,0.0001222234,0.0004394586],"domain_scores_gemma":[0.9983729,0.00003778774,0.0003047288,0.0002719569,0.0005467694,0.0004659002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008687369,0.000001577595,0.0005550703,0.0003647562,0.001084019,0.00005044804,0.0000216245,0.0001012696,0.000006190348,0.00002181496,0.01904903,0.9786573],"study_design_scores_gemma":[0.0005642449,0.0009999119,0.000104869,0.0004674877,0.0004002529,0.001390317,0.00004008992,5.622123e-7,0.000003058406,0.00001734131,0.9957815,0.0002303048],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002182137,0.9885451,0.009424618,0.00002804411,0.0002198823,0.0005811197,0.0003210077,0.000001827522,0.0006602011],"genre_scores_gemma":[0.002126473,0.9937441,0.0003018701,0.00002048686,0.002727756,0.00005403487,0.0006453579,0.00007687102,0.0003029861],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.978427,"threshold_uncertainty_score":0.9347209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05310575620969769,"score_gpt":0.339607607466507,"score_spread":0.2865018512568093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}