{"id":"W1757631619","doi":"10.1039/c5md00210a","title":"Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors","year":2015,"lang":"en","type":"article","venue":"MedChemComm","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Wellcome Trust","keywords":"Aryl; Combinatorial chemistry; Chemistry; Pharmacology; Stereochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003182148,0.0001792223,0.0001915845,0.00004616422,0.00004464437,0.000027001,0.0001768913,0.0001402771,0.00000883299],"category_scores_gemma":[0.0000928688,0.0001588821,0.00005251,0.0000930164,0.0001590943,0.00001252631,0.0001566835,0.00007678903,0.00001002981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002057755,"about_ca_system_score_gemma":0.0001976966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003303599,"about_ca_topic_score_gemma":0.000003773931,"domain_scores_codex":[0.9990045,0.00003200294,0.0002522989,0.0002876396,0.0002093434,0.0002142177],"domain_scores_gemma":[0.9993963,0.0000169678,0.0001025255,0.0002514334,0.0001088637,0.0001239151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003263201,0.0001006102,0.005838519,0.00003685786,0.0001089169,0.00001432009,0.0003616514,0.000264088,0.9781082,0.0001117887,0.01261106,0.002117725],"study_design_scores_gemma":[0.0007495341,0.0001613087,0.0003706944,0.00003816828,0.00002721861,0.00002374182,0.0001445388,0.00003524369,0.9903629,0.00036773,0.007488964,0.0002299652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883604,0.003462757,0.006790279,0.000263443,0.0003351209,0.0001874079,0.000005472463,0.0000174995,0.0005775964],"genre_scores_gemma":[0.9957582,0.0002783179,0.002763442,0.0001616401,0.0001867489,0.00002819667,0.00006024368,0.00002250237,0.0007407075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01225476,"threshold_uncertainty_score":0.6479024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281597066753873,"score_gpt":0.2494814274938194,"score_spread":0.2266654568262807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}