{"id":"W1758507680","doi":"10.4049/jimmunol.165.2.786","title":"Engagement of CD153 (CD30 Ligand) by CD30+ T Cells Inhibits Class Switch DNA Recombination and Antibody Production in Human IgD+ IgM+ B Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; Cancer Research Institute; Kitasato University; National Institute on Aging; Hospital for Special Surgery","keywords":"Immunoglobulin class switching; Immunoglobulin D; Molecular biology; CD40; CD154; Biology; B cell; CD19; Immunoglobulin E; Antibody; Chemistry; Immunology; Cytotoxic T cell; In vitro; Flow cytometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001843897,0.0002952261,0.000694711,0.000359624,0.0002894797,0.00001318328,0.0004956523,0.0004609671,0.0004894891],"category_scores_gemma":[0.00005123201,0.0002223067,0.0001153345,0.0002878088,0.0006915373,0.0002138536,0.0001310641,0.001244563,0.00008975741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000925658,"about_ca_system_score_gemma":0.00008322779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001925951,"about_ca_topic_score_gemma":0.00003404044,"domain_scores_codex":[0.9966387,0.001345147,0.001171042,0.0002796807,0.00008066009,0.0004847363],"domain_scores_gemma":[0.9983208,0.0002361359,0.0008332064,0.0003965484,0.0001925155,0.00002078509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000727737,0.0007277852,0.0002571369,0.00002695279,0.0003207401,0.000005872924,0.001654957,0.0000219341,0.9850431,0.00008157569,0.002333453,0.008798755],"study_design_scores_gemma":[0.003057432,0.001504342,0.001556526,0.0001004023,0.0001138417,0.0003868252,0.0008000735,0.000001328965,0.9786949,0.0005131426,0.01306717,0.0002040725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875749,0.008994104,0.00001119296,0.001196036,0.001343195,0.0003408291,0.000008650856,0.00001949787,0.0005116189],"genre_scores_gemma":[0.9893683,0.007317876,0.00002019612,0.00008448094,0.00004457978,0.000004425653,0.00002916491,0.00002523634,0.003105757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01073371,"threshold_uncertainty_score":0.9065403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009823741462733253,"score_gpt":0.2354974402156128,"score_spread":0.2256736987528795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}