{"id":"W1758507680","doi":"10.4049/jimmunol.165.2.786","title":"Engagement of CD153 (CD30 Ligand) by CD30+ T Cells Inhibits Class Switch DNA Recombination and Antibody Production in Human IgD+ IgM+ B Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; Cancer Research Institute; Kitasato University; National Institute on Aging; Hospital for Special Surgery","keywords":"Immunoglobulin class switching; Immunoglobulin D; Molecular biology; CD40; CD154; Biology; B cell; CD19; Immunoglobulin E; Antibody; Chemistry; Immunology; Cytotoxic T cell; In vitro; Flow cytometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234126,0.0002101787,0.0002676811,0.00009732929,0.00008521224,0.000196455,0.000133117,0.0001750524,0.0009749755],"category_scores_gemma":[0.0001154147,0.000105349,0.0002116796,0.00006874687,0.000106183,0.00007263492,0.000122515,0.0003359325,0.0003441919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000156478,"about_ca_system_score_gemma":0.0001638383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004650087,"about_ca_topic_score_gemma":0.0006715786,"domain_scores_codex":[0.999853,0.0000329725,0.00001805633,0.00001690541,0.00002800467,0.00005103915],"domain_scores_gemma":[0.9999212,0.00001783377,0.00001749332,0.000009466822,0.000005636678,0.00002830754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002398392,0.00009324622,0.0001177995,0.00001679469,0.000003635502,0.0000333376,0.000009072072,0.00005239596,0.9984047,0.00002314215,0.00003093603,0.0009750524],"study_design_scores_gemma":[0.00006753331,0.002424935,0.003598496,0.000004545546,0.00001451426,0.0002535715,0.0000197378,0.0008529283,0.9916962,0.00001620274,0.001048736,0.00000268709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986179,0.0003876399,0.0002697664,0.00002187415,0.000009500199,0.00001170837,0.00004984632,0.0000263151,0.0006055031],"genre_scores_gemma":[0.9983153,0.0002771998,0.0003655005,0.00003310906,0.00000793969,0.00001806367,0.0002206304,0.000005639407,0.0007565742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009749755,"threshold_uncertainty_score":0.003261626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009823741462733253,"score_gpt":0.2354974402156128,"score_spread":0.2256736987528795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}