{"id":"W1759000000","doi":"10.1111/j.1537-2995.2011.03421.x","title":"Hemodynamic responses to a hemoglobin bis‐tetramer and its polyethylene glycol conjugate","year":2011,"lang":"en","type":"article","venue":"Transfusion","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Massachusetts General Hospital","keywords":"Hemoglobin; Blood substitute; Nitric oxide; Polyethylene glycol; PEG ratio; Chemistry; Nitrite; Vasodilation; Vascular resistance; Hemodynamics; In vivo; Pharmacology; Deoxygenated Hemoglobin; Medicine; Biochemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148596,0.0001735464,0.0001390808,0.00006796767,0.00009476214,0.00001259909,0.00009674594,0.0001750919,0.0001055886],"category_scores_gemma":[0.00002952486,0.000157441,0.00005640209,0.0001170426,0.00003627139,0.000006132786,0.00003929033,0.00008475746,0.00002386164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001038615,"about_ca_system_score_gemma":0.00004309748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008976701,"about_ca_topic_score_gemma":0.00008066174,"domain_scores_codex":[0.9990466,0.00005621169,0.0001652345,0.0003898177,0.0001039466,0.0002381663],"domain_scores_gemma":[0.9995451,0.000008193805,0.00002455795,0.0002187157,0.00005143068,0.0001519815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001240371,0.00003108506,0.0009659642,0.00001618724,0.00001852344,0.000006411959,0.0002481872,0.000001287841,0.9906241,0.00007757983,0.0002098585,0.006560478],"study_design_scores_gemma":[0.0009575823,0.0009346821,0.02009398,0.00002199258,0.00003308221,0.0000782784,0.00008103353,0.0000431197,0.9605906,0.00008088434,0.0167756,0.0003091396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939376,0.0004020541,0.002579566,0.000171614,0.0002084172,0.000360666,0.00003238964,0.00003044346,0.002277251],"genre_scores_gemma":[0.9970844,0.0003580426,0.0006602526,0.0006975534,0.00009132573,0.00002180153,0.00002785124,0.00002434545,0.00103447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03003344,"threshold_uncertainty_score":0.6420259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522605593924494,"score_gpt":0.2384062508551453,"score_spread":0.2231801949159003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}