{"id":"W1759080653","doi":"10.1139/o11-081","title":"Breast cancer cells adapt to metabolic stress by increasing ethanolamine phospholipid synthesis and CTP:ethanolaminephosphate cytidylyltransferase-Pcyt2 activity","year":2012,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Phosphatidylethanolamine; Diacylglycerol kinase; Enzyme; Biochemistry; Phosphorylation; Biosynthesis; Cancer cell; Metabolism; Phospholipid; Chemistry; Biology; Cancer; Internal medicine; Phosphatidylcholine; Protein kinase C; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003691777,0.0004971091,0.0004897559,0.00004695668,0.0001966129,0.00004108854,0.0002547951,0.0005564222,0.00007189719],"category_scores_gemma":[0.0000504128,0.0004410268,0.00009591312,0.0001333875,0.0002052677,0.00001978208,0.0002314855,0.0001753347,0.000006210232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001583139,"about_ca_system_score_gemma":0.00006632034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325115,"about_ca_topic_score_gemma":0.00001067853,"domain_scores_codex":[0.997888,0.0001540455,0.0002817938,0.0007855011,0.0001142373,0.0007764543],"domain_scores_gemma":[0.9987983,0.00007884481,0.0001185389,0.0004333265,0.00006308194,0.0005079151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003829262,0.0002242092,0.00471541,0.0001143404,0.0001024753,6.310624e-7,0.00006056706,4.532871e-7,0.9553064,0.000003835974,0.0003224236,0.03876632],"study_design_scores_gemma":[0.0004203185,0.00004206501,0.00489945,0.00002460286,0.0001495763,0.00003707053,0.00006435357,0.000003075747,0.9431284,6.324591e-7,0.05068367,0.000546801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733043,0.02425459,0.00009604282,0.0002013276,0.0002717809,0.0002040116,0.001341672,0.00003277223,0.0002935189],"genre_scores_gemma":[0.9929267,0.005022109,0.000358323,0.0002509659,0.0008483896,0.00007779094,0.000119662,0.00004907443,0.0003470181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05036125,"threshold_uncertainty_score":0.9998041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005831861170187427,"score_gpt":0.2180233011648667,"score_spread":0.2121914399946793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}