{"id":"W1759167934","doi":"10.4049/jimmunol.0900432","title":"Phosphoinositide 3-Kinase p110δ Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"B cell; Marginal zone; Biology; Cell biology; breakpoint cluster region; PI3K/AKT/mTOR pathway; Chemotaxis; Phosphoinositide 3-kinase; B-cell receptor; Immunology; Antibody; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120701,0.0003150558,0.0001693849,0.0002556766,0.0001866606,0.0004305585,0.0002621078,0.0002139951,0.0005999288],"category_scores_gemma":[0.0001290182,0.0002044962,0.0001530493,0.0001491247,0.0003446092,0.0001795549,0.0002441467,0.000590514,0.0002906739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000356612,"about_ca_system_score_gemma":0.0003146035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005583051,"about_ca_topic_score_gemma":0.0006292393,"domain_scores_codex":[0.9998834,0.00001790143,0.000007514473,0.00002576007,0.00002292647,0.00004248154],"domain_scores_gemma":[0.9999167,0.000006529402,0.00002772773,0.000005287157,0.000005513667,0.00003822819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001095067,0.0001357637,0.002361552,0.0001002738,0.00001452533,0.0001498928,0.00002935228,0.0002183117,0.9854054,0.0005598986,0.0003850069,0.009544911],"study_design_scores_gemma":[0.0003876152,0.00100005,0.1479769,0.00004354554,0.0001185423,0.001338969,0.0001931335,0.005698656,0.831199,0.001242942,0.01077877,0.00002179393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909316,0.00489281,0.001410986,0.0001599956,0.00003674613,0.00001425971,0.000141816,0.0001153427,0.002296427],"genre_scores_gemma":[0.9961603,0.001716622,0.0004562448,0.00005927899,0.00001309312,0.00001858496,0.0001677731,0.00001300655,0.00139512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005999288,"threshold_uncertainty_score":0.002587438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004539045725343985,"score_gpt":0.2386800935501872,"score_spread":0.2341410478248432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}