{"id":"W1759653963","doi":"10.1002/ptr.4763","title":"Anti‐diabetic Activity of Swertiamarin is due to an Active Metabolite, Gentianine, that Upregulates PPAR‐γ Gene Expression in 3T3‐L1 cells","year":2012,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Adiponectin; Adipogenesis; Metabolite; Internal medicine; Endocrinology; Active metabolite; Chemistry; Peroxisome proliferator-activated receptor; Medicine; Insulin resistance; Diabetes mellitus; Adipose tissue; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009069199,0.0002878855,0.000435959,0.0003418221,0.0001097207,0.00003949294,0.0004891469,0.0002963835,0.000256685],"category_scores_gemma":[0.00005057352,0.0002605394,0.0001133269,0.0005834072,0.0001593493,0.00006239787,0.0002602333,0.0003662918,0.0000231598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005970573,"about_ca_system_score_gemma":0.0001122704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001053282,"about_ca_topic_score_gemma":0.00001834237,"domain_scores_codex":[0.9968589,0.0006996818,0.00025497,0.0006320074,0.0005827595,0.0009716921],"domain_scores_gemma":[0.9984671,0.0000518959,0.00009906075,0.0007919274,0.0002203766,0.0003696267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007143898,0.0007192698,0.0324512,0.00003291315,0.00008456663,0.000001389299,0.0008097492,0.00002804936,0.9592487,0.000002219321,0.0003551796,0.005552358],"study_design_scores_gemma":[0.0006431223,0.0002927888,0.05137642,0.00002536354,0.000005128813,0.000002709482,0.0001049514,0.00002612692,0.9449479,0.00002623246,0.002284687,0.0002645823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970324,0.001609863,0.0001753819,0.000095326,0.0001592814,0.0006659737,0.00007999254,0.00001519098,0.0001665983],"genre_scores_gemma":[0.9973894,0.0006221973,0.001076678,0.0000963896,0.0002902809,0.0001409967,0.0000396039,0.00007835634,0.0002661272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01892523,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04527027042970073,"score_gpt":0.3466009651436171,"score_spread":0.3013306947139164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}