{"id":"W1759653963","doi":"10.1002/ptr.4763","title":"Anti‐diabetic Activity of Swertiamarin is due to an Active Metabolite, Gentianine, that Upregulates PPAR‐γ Gene Expression in 3T3‐L1 cells","year":2012,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Adiponectin; Adipogenesis; Metabolite; Internal medicine; Endocrinology; Active metabolite; Chemistry; Peroxisome proliferator-activated receptor; Medicine; Insulin resistance; Diabetes mellitus; Adipose tissue; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322843,0.0003367404,0.0002995406,0.0003225337,0.0001314828,0.0001982165,0.0001195253,0.0002156087,0.001248034],"category_scores_gemma":[0.00007777559,0.0001194964,0.0004435866,0.0002157778,0.0001868923,0.0001349557,0.0001235386,0.0005108716,0.0002106453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542919,"about_ca_system_score_gemma":0.0001722883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007606837,"about_ca_topic_score_gemma":0.001670735,"domain_scores_codex":[0.9999361,0.00001830973,0.00000621182,0.00001342553,0.00001303172,0.00001301935],"domain_scores_gemma":[0.9999611,0.00001011485,0.000009180371,0.000006330806,0.000005946442,0.000007284815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000201669,0.00004248437,0.0001061292,0.0000348784,0.000008056941,0.00003914247,0.000009061383,0.00004314304,0.9978105,0.00004632348,0.00001794409,0.001640717],"study_design_scores_gemma":[0.00005010298,0.0007138977,0.004968992,0.000006310227,0.0000423863,0.0001803724,0.00001810119,0.0003341192,0.991416,0.00005044709,0.002213659,0.000005538524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896478,0.004081851,0.003279805,0.0001591749,0.00004572391,0.00003349971,0.0003573772,0.00008208677,0.002312677],"genre_scores_gemma":[0.9932311,0.001971242,0.002118591,0.00008123369,0.00001145484,0.00001907274,0.0004028859,0.00001534888,0.002149087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248034,"threshold_uncertainty_score":0.004175067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04527027042970073,"score_gpt":0.3466009651436171,"score_spread":0.3013306947139164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}