{"id":"W1759800933","doi":"10.1002/pro.2680","title":"Protein structural dynamics at the gas/water interface examined by hydrogen exchange mass spectrometry","year":2015,"lang":"en","type":"article","venue":"Protein Science","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Hydrogen–deuterium exchange; Chemical physics; Myoglobin; Mass spectrometry; Protein folding; Conformational isomerism; Protein dynamics; Sparging; Molecular dynamics; Kinetics; Protein structure; Crystallography; Biophysics; Computational chemistry; Physical chemistry; Molecule; Chromatography; Physics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006400879,0.0001841261,0.000111511,0.00004684414,0.0002387367,0.00008363542,0.0005713149,0.0001005092,0.0000726189],"category_scores_gemma":[0.000125304,0.0001090832,0.00004237402,0.0002726631,0.0005037861,0.00002080367,0.000392476,0.0001205114,0.00004604919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765353,"about_ca_system_score_gemma":0.00008512734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000441399,"about_ca_topic_score_gemma":0.00003979984,"domain_scores_codex":[0.9983579,0.00006218111,0.0001667732,0.0005207311,0.0004184519,0.0004739479],"domain_scores_gemma":[0.9991294,0.000002771072,0.00006765643,0.0005158436,0.0001230761,0.0001612346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006106855,0.000004613278,0.0001624677,0.00000758854,0.000006659519,0.000001113453,0.00007154969,0.000008897386,0.9971551,0.0000263346,0.0004411139,0.002053491],"study_design_scores_gemma":[0.0002584825,0.0002603114,0.00007418919,0.000005921473,0.000004656539,0.00002681302,0.00007628086,0.0005539177,0.990093,0.0004733903,0.007992125,0.000180914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921056,0.0004425549,0.004286244,0.0005654802,0.0001700794,0.0006937033,0.00002288574,0.00002138457,0.001692093],"genre_scores_gemma":[0.9935026,0.000003039278,0.001012881,0.0001029591,0.0001535002,0.00007564882,0.00005499112,0.00001594763,0.0050784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007551011,"threshold_uncertainty_score":0.4448285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009588835577963266,"score_gpt":0.238798149889327,"score_spread":0.2292093143113638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}