{"id":"W1763737827","doi":"10.1593/neo.92048","title":"Cisplatin Induces Cytotoxicity through the Mitogen-Activated Protein Kinase Pathways ana Activating Transcription Factor 3","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cisplatin; MAPK/ERK pathway; Cytotoxicity; Protein kinase A; Kinase; Biology; p38 mitogen-activated protein kinases; Cell biology; Chemistry; Cancer research; Molecular biology; Biochemistry; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312516,0.0002465139,0.0001536795,0.00002488388,0.0002375687,0.00005859706,0.0002925629,0.0003401175,0.00009112772],"category_scores_gemma":[0.0001805696,0.0001880791,0.0001179165,0.0001406528,0.0000772545,0.00002067325,0.00006425847,0.0004191178,0.00001543446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001743833,"about_ca_system_score_gemma":0.00009890726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007409045,"about_ca_topic_score_gemma":0.0001407294,"domain_scores_codex":[0.9986776,0.000101425,0.0002303283,0.0004422137,0.0002203355,0.0003281331],"domain_scores_gemma":[0.9991767,0.00001993921,0.0001460943,0.0005093499,0.00007459823,0.00007335768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008793086,0.00005514997,0.00007680635,0.00001307986,0.00003335828,0.000003126436,0.0005608141,0.000003186515,0.9947077,0.000265461,0.00008147811,0.004111921],"study_design_scores_gemma":[0.000441781,0.000196745,0.001193477,0.00001452095,0.000007750062,0.00001551472,0.0002279248,0.00003615114,0.9920952,0.0002409952,0.005305097,0.0002248574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996839,0.00003123195,0.0008930741,0.000131655,0.0004176891,0.0006404726,0.00004924988,0.00006997435,0.0009275971],"genre_scores_gemma":[0.9972281,0.000004403189,0.001877431,0.0001391253,0.000296527,0.000110166,0.00006858538,0.00004156528,0.0002340668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005223619,"threshold_uncertainty_score":0.7669642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01924529411279499,"score_gpt":0.2437548382799539,"score_spread":0.2245095441671589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}