{"id":"W1763737827","doi":"10.1593/neo.92048","title":"Cisplatin Induces Cytotoxicity through the Mitogen-Activated Protein Kinase Pathways ana Activating Transcription Factor 3","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cisplatin; MAPK/ERK pathway; Cytotoxicity; Protein kinase A; Kinase; Biology; p38 mitogen-activated protein kinases; Cell biology; Chemistry; Cancer research; Molecular biology; Biochemistry; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078652,0.0003204012,0.0002117872,0.0002555243,0.0001515802,0.0002154605,0.0001184978,0.000178738,0.0009656703],"category_scores_gemma":[0.0001203244,0.0001078079,0.0004325564,0.0001437227,0.0001191723,0.0001933355,0.000193864,0.0004184321,0.0002568837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236702,"about_ca_system_score_gemma":0.0002364471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221171,"about_ca_topic_score_gemma":0.0002846482,"domain_scores_codex":[0.9998814,0.0000175528,0.0000134219,0.00001657603,0.00004638496,0.0000246406],"domain_scores_gemma":[0.999933,0.00001322938,0.00001903376,0.000008490622,0.00001418444,0.00001206735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008483209,0.00002505812,0.0003834633,0.0000512083,0.000008203773,0.0001190103,0.000009781817,0.0001091796,0.9967896,0.0001031864,0.00008218954,0.002234263],"study_design_scores_gemma":[0.00002186861,0.0003322632,0.01409761,0.00001137391,0.00002298009,0.0009331498,0.00003032068,0.001292993,0.9786769,0.0002099578,0.00436374,0.000006916787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831613,0.003579349,0.008428941,0.0002114528,0.00008525712,0.00009447414,0.0006449514,0.0001955762,0.003598775],"genre_scores_gemma":[0.9931865,0.002319647,0.002320408,0.0001014997,0.00001454381,0.00007267456,0.0006669712,0.0000128826,0.001304804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009656703,"threshold_uncertainty_score":0.003230512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01924529411279499,"score_gpt":0.2437548382799539,"score_spread":0.2245095441671589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}