{"id":"W176409249","doi":"10.1007/bf03256467","title":"Use of Biomarkers in Clinical Trials of Alzheimer Disease","year":2011,"lang":"en","type":"article","venue":"Molecular Diagnosis & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Disease; Clinical trial; Medicine; Human genetics; Alzheimer's disease; Intensive care medicine; Molecular medicine; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06268743,0.001916593,0.005871806,0.00227844,0.001269254,0.003693988,0.00095497,0.003784596,0.002726411],"category_scores_gemma":[0.09315415,0.001074257,0.002330304,0.00249993,0.002032322,0.005115369,0.001609484,0.002942494,0.000598478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001918321,"about_ca_system_score_gemma":0.003224358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004149056,"about_ca_topic_score_gemma":0.0008051107,"domain_scores_codex":[0.8990924,0.08705756,0.005825773,0.002710587,0.004249311,0.001064394],"domain_scores_gemma":[0.9262884,0.04736447,0.01617365,0.003743221,0.004031039,0.002399203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5331216,0.003018581,0.08560493,0.008381063,0.01503415,0.0003837606,0.0006272563,0.002391133,0.006550957,0.007353272,0.007002934,0.3305303],"study_design_scores_gemma":[0.31453,0.2886544,0.175596,0.007408394,0.03192622,0.001871471,0.0008668234,0.008587438,0.01819409,0.03778012,0.1139178,0.0006671287],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3766643,0.5519065,0.01657818,0.01654761,0.009072675,0.006083565,0.00285543,0.0003183353,0.01997338],"genre_scores_gemma":[0.948635,0.03008836,0.01024114,0.002939513,0.001463867,0.004654413,0.0008258429,0.00003842493,0.001113464],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.06268743,"threshold_uncertainty_score":0.3315268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3081583344749549,"score_gpt":0.4463053786447118,"score_spread":0.1381470441697569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}