{"id":"W1766553222","doi":"10.1039/c5md00241a","title":"Discovery of high affinity inhibitors of <i>Leishmania donovani N</i>-myristoyltransferase","year":2015,"lang":"en","type":"article","venue":"MedChemComm","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kensington Health","funders":"Medical Research Council; Diamond Light Source; Seventh Framework Programme; Wellcome Trust; Wellcome","keywords":"Leishmania donovani; Leishmania; Chemistry; Biology; Stereochemistry; Leishmaniasis; Genetics; Visceral leishmaniasis; Computer science; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002648785,0.0003785549,0.0002530719,0.0001880483,0.0001452639,0.0002997315,0.0002353797,0.0002183751,0.0008766589],"category_scores_gemma":[0.0001694542,0.0001692127,0.0001533815,0.0001429076,0.000174444,0.0001684433,0.0002206467,0.0005290509,0.0003471318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005021287,"about_ca_system_score_gemma":0.0003063906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006486347,"about_ca_topic_score_gemma":0.002370192,"domain_scores_codex":[0.9999146,0.00001720667,0.000005127406,0.00001356509,0.00002183811,0.00002766808],"domain_scores_gemma":[0.9999655,0.000006248383,0.000006380323,0.000003158205,0.000009437943,0.000009136079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977314,0.00008038209,0.0002085991,0.00009158945,0.00001175871,0.00008722649,0.00002606048,0.0004965806,0.9871811,0.000722841,0.0005575576,0.01033862],"study_design_scores_gemma":[0.00007813243,0.0004208368,0.0004678389,0.000009033237,0.0000132564,0.0002604563,0.00001109106,0.001229011,0.986974,0.00007594466,0.0104535,0.000006904445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360612,0.01111248,0.03153652,0.001046989,0.0001222578,0.0004465957,0.0008804997,0.0005281587,0.01826528],"genre_scores_gemma":[0.9776424,0.005149973,0.009457921,0.0002028289,0.00001669326,0.00009398181,0.0008738604,0.00003329355,0.006529049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008766589,"threshold_uncertainty_score":0.003643155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04233933231031607,"score_gpt":0.2976081216272644,"score_spread":0.2552687893169483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}