{"id":"W1766624150","doi":"10.1080/15287394.2015.1028119","title":"Kinetics of Diol and Hydroxybenzo[a]pyrene Metabolites in Relation to DNA Adduct Formation and Gene Expression in Rats","year":2015,"lang":"en","type":"article","venue":"Journal of Toxicology and Environmental Health","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de Santé Publique du Québec; Université de Montréal","funders":"Université de Montréal; Institut National de Santé Publique du Québec","keywords":"Carcinogen; Pyrene; Chemistry; DNA adduct; Gene expression; Benzo(a)pyrene; Gene; Carcinogenesis; Adduct; Oxidative stress; DNA; Molecular biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230515,0.0003567157,0.0002521345,0.000591606,0.0001106801,0.0002731265,0.000134855,0.0003199397,0.0008656127],"category_scores_gemma":[0.0002157117,0.0003027384,0.0002731302,0.0003190195,0.0002225848,0.0002559542,0.0001227073,0.0004974166,0.0004128172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363309,"about_ca_system_score_gemma":0.0001825618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049125,"about_ca_topic_score_gemma":0.001165976,"domain_scores_codex":[0.9998658,0.00001754219,0.000005440746,0.00005222297,0.00002982075,0.0000291234],"domain_scores_gemma":[0.9996334,0.00005225248,0.0001452473,0.00002717584,0.00005783105,0.00008410244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001304682,0.00008597602,0.004151882,0.00002339424,0.00001828176,0.00004614129,0.00006096472,0.0001268397,0.9912196,0.00003305478,0.00002707743,0.002902162],"study_design_scores_gemma":[0.00003073483,0.002774724,0.08661952,0.000005966076,0.00006867223,0.000188634,0.0001274927,0.00134107,0.907696,0.0001322117,0.0009918468,0.00002302817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996865,0.000724527,0.001459415,0.00003519483,0.00000855496,0.0000134629,0.0005130104,0.00004619959,0.0003346971],"genre_scores_gemma":[0.9891579,0.001207855,0.002122456,0.00006656349,0.00001005844,0.00008566213,0.001102515,0.00003353272,0.006213361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049125,"threshold_uncertainty_score":0.002895772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494864457068236,"score_gpt":0.2697869414853994,"score_spread":0.254838296914717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}