{"id":"W176944265","doi":"10.1177/135965350100600206","title":"Avanti 3: A Randomized, Double-Blind Trial to Compare the Efficacy and Safety of Lamivudine plus Zidovudine versus Lamivudine plus Zidovudine plus Nelfinavir in HIV-1-Infected Antiretroviral-Naive Patients","year":2001,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; St. Paul's Hospital","funders":"","keywords":"Lamivudine; Nelfinavir; Zidovudine; Medicine; Tolerability; Placebo; Gastroenterology; Internal medicine; Adverse effect; Pharmacology; Randomized controlled trial; Indinavir; Virology; Sida; Viral load; Human immunodeficiency virus (HIV); Viral disease; Antiretroviral therapy; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002569862,0.001711238,0.003914948,0.0005786741,0.0005554961,0.001003267,0.001225539,0.002217976,0.006313808],"category_scores_gemma":[0.00287873,0.0008899023,0.001964242,0.0005001909,0.001516787,0.001033301,0.0004611827,0.002560778,0.0009492456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005908264,"about_ca_system_score_gemma":0.000979885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006205025,"about_ca_topic_score_gemma":0.001147648,"domain_scores_codex":[0.9984193,0.001093579,0.0001001131,0.0001993427,0.00007553738,0.0001121753],"domain_scores_gemma":[0.9980789,0.0007439208,0.0004702818,0.0001328053,0.00008209424,0.0004919058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9906143,0.001844944,0.000157534,0.0002155707,0.0003044966,0.00001423353,0.00001307559,0.00009262599,0.001095848,0.00003951326,0.0001705239,0.005437205],"study_design_scores_gemma":[0.9673605,0.03146684,0.0004248556,0.00001124608,0.0001502631,0.00001898237,0.000005444415,0.0002274582,0.0001509575,0.00005954467,0.0001173282,0.000006546726],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836367,0.006727403,0.001336885,0.000812331,0.000978869,0.003514793,0.001088071,0.0002977327,0.001607316],"genre_scores_gemma":[0.9846681,0.002654027,0.003124096,0.001266788,0.001082728,0.004676746,0.0008208321,0.00003486414,0.001671783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006313808,"threshold_uncertainty_score":0.02112174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04664450726182794,"score_gpt":0.318903719057104,"score_spread":0.2722592117952761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}