{"id":"W1769491266","doi":"10.1128/jcm.00650-15","title":"Development and Validation of Two Screening Assays for the Hepatitis C Virus NS3 Q80K Polymorphism Associated with Reduced Response to Combination Treatment Regimens Containing Simeprevir","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Microbiology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver","funders":"Canadian Institutes of Health Research","keywords":"Simeprevir; Genotyping; Virology; Sanger sequencing; Hepatitis C virus; Biology; NS3; Genotype; Single-nucleotide polymorphism; Concordance; Ribavirin; Genetics; DNA sequencing; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006156895,0.001218387,0.001056723,0.002174905,0.0003951932,0.001138689,0.001150356,0.001713806,0.0006367821],"category_scores_gemma":[0.008714218,0.0007775156,0.000946354,0.0008321214,0.0009172059,0.0003849789,0.0009486804,0.0009015675,0.0006928447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007002335,"about_ca_system_score_gemma":0.000843936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001609756,"about_ca_topic_score_gemma":0.001738364,"domain_scores_codex":[0.988043,0.003805091,0.0008135044,0.002499984,0.004356426,0.0004820121],"domain_scores_gemma":[0.9952677,0.001720988,0.0007488478,0.0006586714,0.001270408,0.0003332472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003140458,0.001550664,0.1139975,0.0002944014,0.0003380236,0.0001519288,0.0005380738,0.002931144,0.8263349,0.0002265551,0.0004396299,0.05005671],"study_design_scores_gemma":[0.0007948946,0.007754127,0.2140789,0.0001077933,0.0005459902,0.001791239,0.0001932191,0.03695023,0.7330443,0.0002189259,0.004364385,0.0001560856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9413731,0.0009579914,0.05192517,0.0001863433,0.00009432241,0.00122404,0.001711667,0.0005002095,0.002027092],"genre_scores_gemma":[0.8987751,0.0002976769,0.0938178,0.0003495303,0.00003629745,0.001366659,0.003662589,0.0001055272,0.001588766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006156895,"threshold_uncertainty_score":0.03256112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1824006628409766,"score_gpt":0.4377139194360804,"score_spread":0.2553132565951037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}