{"id":"W1769517315","doi":"10.1016/j.ebiom.2015.09.048","title":"Paradox of Protection: Preferential Recognition of CD4-induced Epitopes by Anti-HIV-1 ADCC Antibodies","year":2015,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Antibody; Human immunodeficiency virus (HIV); Vaccine trial; Medicine; Epitope; Virology; Immunology; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001463068,0.0002333683,0.0006771794,0.0004804058,0.0002215439,0.001139106,0.0006979496,0.001167328,0.005974534],"category_scores_gemma":[0.003474596,0.0001810485,0.0002686239,0.0002914034,0.0008665402,0.001346792,0.0006085105,0.001442209,0.001430138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165712,"about_ca_system_score_gemma":0.00057828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007035814,"about_ca_topic_score_gemma":0.0008191844,"domain_scores_codex":[0.9994703,0.000158264,0.00002676516,0.00009335456,0.0001466801,0.0001046816],"domain_scores_gemma":[0.9984505,0.0007695002,0.0002845042,0.0001804295,0.0001752186,0.0001398928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008570759,0.001148473,0.04328209,0.003223947,0.0005029495,0.007802362,0.001211459,0.00207984,0.1035592,0.1044341,0.09895959,0.6252254],"study_design_scores_gemma":[0.003282392,0.007599611,0.2477087,0.002037265,0.0007772219,0.05653096,0.003052806,0.01113248,0.1181208,0.2204496,0.3290846,0.0002235542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5250185,0.2688104,0.006969134,0.08010502,0.001112863,0.0001114831,0.0009480485,0.0004340602,0.1164906],"genre_scores_gemma":[0.9601111,0.02363487,0.0006300715,0.009710487,0.000517925,0.00003630918,0.0001688221,0.00002819802,0.005162186],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.005974534,"threshold_uncertainty_score":0.01998681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05130325544172699,"score_gpt":0.2841014824423896,"score_spread":0.2327982270006627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}