{"id":"W1769581193","doi":"10.1016/bs.pmbts.2015.06.005","title":"A2E and Lipofuscin","year":2015,"lang":"en","type":"review","venue":"Progress in molecular biology and translational science","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Eye Institute; National Institutes of Health; AGE-WELL","keywords":"Lipofuscin; Retinal pigment epithelium; Macular degeneration; Retinal; Chemistry; Retina; Anatomy; Biology; Cell biology; Pathology; Biochemistry; Ophthalmology; Neuroscience; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002721208,0.0001543859,0.0004486605,0.0001654324,0.00005632941,0.00001732008,0.00007363262,0.0001222687,0.000005739526],"category_scores_gemma":[0.00001474562,0.0001045426,0.00005742874,0.0003042754,0.001050549,0.00003630909,0.00003157643,0.0001228348,0.000002777262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001363259,"about_ca_system_score_gemma":0.0003478617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002789382,"about_ca_topic_score_gemma":8.87281e-7,"domain_scores_codex":[0.9990344,0.00005005591,0.0001811697,0.0003976061,0.0001537323,0.0001830447],"domain_scores_gemma":[0.9996248,0.00002543826,0.00005053719,0.00009615337,0.00004548275,0.0001576254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001510849,0.0000560651,0.02293014,0.0008417136,0.00002836779,0.00007288329,0.00001137032,3.092275e-8,8.840059e-7,0.005770226,5.796604e-7,0.9702727],"study_design_scores_gemma":[0.003834251,0.001189577,0.08071157,0.01197384,0.002284849,0.001459737,0.00001490992,0.0001679275,0.00001004656,0.0269806,0.8703054,0.001067359],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001204724,0.997799,0.00004643063,0.0001194615,0.00003202366,0.0004196651,0.00002070125,0.000007710948,0.0003502346],"genre_scores_gemma":[0.01052563,0.9872773,0.001998555,0.00002748349,0.00001727042,0.00005934288,0.00007836177,0.000007315844,0.00000878999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9692053,"threshold_uncertainty_score":0.4263124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03848158967390738,"score_gpt":0.4389911921574032,"score_spread":0.4005096024834959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}