{"id":"W1770114964","doi":"10.1111/j.1365-2613.2011.00805.x","title":"H‐Ras increases release of sphingosine resulting in down‐regulation of TSP‐1 in non‐transformed cells","year":2012,"lang":"en","type":"article","venue":"International Journal of Experimental Pathology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Sphingosine; Angiogenesis; Sphingolipid; Thrombospondin 1; MAPK/ERK pathway; Cell biology; Biology; Sphingosine kinase 1; Cancer research; Chemistry; Kinase; Sphingosine-1-phosphate; Molecular biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008386438,0.000242977,0.0002018452,0.0001575671,0.00008028644,0.0001891082,0.0001157436,0.0001626666,0.001318383],"category_scores_gemma":[0.00009945603,0.0001012337,0.0002100397,0.0001274032,0.0001189401,0.0001285644,0.0001772273,0.000355863,0.000440019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214428,"about_ca_system_score_gemma":0.0001086202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006805168,"about_ca_topic_score_gemma":0.0008002376,"domain_scores_codex":[0.9999019,0.00001830749,0.00001037484,0.00001408643,0.00003433729,0.00002098182],"domain_scores_gemma":[0.999895,0.00003404934,0.00001945303,0.00001446931,0.00001318264,0.00002381377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004474812,0.00001259555,0.00006163138,0.00001170917,0.000001774191,0.00003135945,0.000008722875,0.000009176479,0.9995657,0.00001167389,0.00000906368,0.0002318675],"study_design_scores_gemma":[0.000004940365,0.0001691389,0.003366424,0.000001714037,0.000005011087,0.0001219179,0.00001682452,0.0003239266,0.9953329,0.00001364425,0.0006419534,0.00000158823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970582,0.000712341,0.0009039685,0.00005258207,0.00001662045,0.00001683466,0.0002835482,0.00004826573,0.0009077671],"genre_scores_gemma":[0.995031,0.0006259576,0.001304028,0.00003460995,0.000009911292,0.0000212739,0.0004874824,0.00001443806,0.002471271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318383,"threshold_uncertainty_score":0.004410446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008653615841880883,"score_gpt":0.2837088359465376,"score_spread":0.2750552201046567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}