{"id":"W1770207329","doi":"10.1136/bmj.h5411","title":"Paroxetine and Study 329: what we already knew and when","year":2015,"lang":"en","type":"letter","venue":"BMJ","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Chlorine Chemistry Council","funders":"","keywords":"Methyllycaconitine; Mecamylamine; Acetylcholine; Neuroscience; Nicotinic agonist; Nicotinic Antagonist; Chemistry; Inhibitory postsynaptic potential; Glutamate receptor; Biophysics; Depolarization; Postsynaptic potential; Acetylcholine receptor; Biology; Nicotinic acetylcholine receptor; Receptor; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001127961,0.0002696884,0.0008728274,0.000281257,0.0002336334,0.00139634,0.0004461811,0.002042712,0.003357715],"category_scores_gemma":[0.001976431,0.0001700846,0.0003666389,0.0003007634,0.0006949963,0.0026844,0.0003186848,0.001787794,0.001298786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008239379,"about_ca_system_score_gemma":0.001038552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0013945,"about_ca_topic_score_gemma":0.004973009,"domain_scores_codex":[0.9995852,0.0001101689,0.00007169483,0.00009203955,0.00007970352,0.00006111937],"domain_scores_gemma":[0.9991797,0.0002830273,0.0001647661,0.00005221825,0.0001796157,0.0001406867],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003503739,0.0004965244,0.01394585,0.0044159,0.0004311389,0.002951673,0.00133129,0.0001164742,0.02168086,0.005207415,0.02673069,0.9191884],"study_design_scores_gemma":[0.001119393,0.004567693,0.08668546,0.00838687,0.001406189,0.01274324,0.004505958,0.0007777082,0.02269483,0.01284219,0.8439711,0.0002993789],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.07938316,0.8235333,0.001003463,0.07896351,0.002056292,0.00009116828,0.0004745962,0.0001029055,0.01439158],"genre_scores_gemma":[0.3172069,0.6299941,0.002817334,0.02525621,0.008902575,0.0001652147,0.0004750782,0.00005462,0.01512796],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.998872,"threshold_uncertainty_score":0.01123267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02999765871885754,"score_gpt":0.2837314843136191,"score_spread":0.2537338255947615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}