{"id":"W1771227799","doi":"10.1371/journal.pgen.1005575","title":"The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Intellectual and Developmental Disabilities Research Center; Stichting Nederlands Oogheelkundig Onderzoek; Landelijke Stichting voor Blinden en Slechtzienden; Foundation Fighting Blindness; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stichting Blindenhulp; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; E-Rare; National Science Foundation; University of Washington; Nierstichting","keywords":"Ciliopathies; Cilium; Ciliopathy; Biology; Cell biology; Ciliogenesis; Zebrafish; Transport protein; Intraflagellar transport; Joubert syndrome; Nephronophthisis; Exocyst; Dynein; Rab; Microtubule; Phenotype; Exocytosis; Genetics; Mutant; GTPase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465672,0.0001585819,0.0001259469,0.00002843022,0.000121756,0.00005844867,0.000138914,0.0001084256,0.000002399139],"category_scores_gemma":[0.0001463157,0.0001150629,0.0000310959,0.000136914,0.0001462459,0.000002645113,0.00007785833,0.00008581457,0.00000720508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000179901,"about_ca_system_score_gemma":0.0001688655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006174547,"about_ca_topic_score_gemma":0.00008159102,"domain_scores_codex":[0.9989506,0.00008966406,0.0001849488,0.0002922161,0.0001877169,0.0002948737],"domain_scores_gemma":[0.9993287,0.00001691095,0.00006456231,0.0002761712,0.0001152729,0.000198378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004610124,0.0004690496,0.04694512,0.00003469424,0.0001941823,0.00001317275,0.0003761612,0.001020974,0.9444093,0.00002503978,0.00325059,0.002800756],"study_design_scores_gemma":[0.005333143,0.002205036,0.03699048,0.0001318565,0.0002157489,0.00003602998,0.002184412,0.005832087,0.9212822,0.0006108547,0.0241983,0.0009798656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946507,0.00415374,0.00005550874,0.0004163496,0.00003782041,0.0003442714,0.00001622003,0.00001813658,0.0003072655],"genre_scores_gemma":[0.9986358,0.00007760807,0.0002930753,0.0001106925,0.00009087586,0.00006117715,0.00003910673,0.00002736703,0.0006642618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02312707,"threshold_uncertainty_score":0.4692129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177063811123892,"score_gpt":0.204479950709469,"score_spread":0.19270931259823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}