{"id":"W1771227799","doi":"10.1371/journal.pgen.1005575","title":"The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Intellectual and Developmental Disabilities Research Center; Stichting Nederlands Oogheelkundig Onderzoek; Landelijke Stichting voor Blinden en Slechtzienden; Foundation Fighting Blindness; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stichting Blindenhulp; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; E-Rare; National Science Foundation; University of Washington; Nierstichting","keywords":"Ciliopathies; Cilium; Ciliopathy; Biology; Cell biology; Ciliogenesis; Zebrafish; Transport protein; Intraflagellar transport; Joubert syndrome; Nephronophthisis; Exocyst; Dynein; Rab; Microtubule; Phenotype; Exocytosis; Genetics; Mutant; GTPase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413981,0.000477783,0.0002519745,0.0005769001,0.0006665587,0.0004910658,0.000328065,0.0006126171,0.001094116],"category_scores_gemma":[0.0001831997,0.0002017453,0.0005182555,0.0002784695,0.0003620095,0.0002694342,0.0009730014,0.0003466083,0.0009254268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0012506,"about_ca_system_score_gemma":0.0004039129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0022778,"about_ca_topic_score_gemma":0.003867063,"domain_scores_codex":[0.9997671,0.00002456002,0.00002024184,0.0000692109,0.00007758322,0.00004130123],"domain_scores_gemma":[0.9998546,0.000008860411,0.00005202202,0.00001461766,0.00001726183,0.00005270913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009645883,0.00001435255,0.003193064,0.00007730738,0.00002168473,0.001059179,0.00002538725,0.00008596794,0.9937075,0.0001941975,0.0001897505,0.001335252],"study_design_scores_gemma":[0.00004965929,0.00009956055,0.09682068,0.00004020404,0.0000661618,0.01146387,0.0001181793,0.004196622,0.865977,0.0002516724,0.02088291,0.00003354986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833302,0.006224998,0.006192763,0.000474275,0.00007207091,0.00003169374,0.0007658338,0.0002039389,0.002704205],"genre_scores_gemma":[0.9921252,0.0009472419,0.002749834,0.0001288077,0.00001542126,0.00003148326,0.001285252,0.00002710036,0.002689678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022778,"threshold_uncertainty_score":0.009073734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177063811123892,"score_gpt":0.204479950709469,"score_spread":0.19270931259823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}