{"id":"W1772980645","doi":"10.4049/jimmunol.168.7.3173","title":"Transgenic Expression of Numb Inhibits Notch Signaling in Immature Thymocytes But Does Not Alter T Cell Fate Specification","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"NUMB; Notch signaling pathway; Biology; Cell biology; Cell fate determination; Thymocyte; Notch proteins; Hes3 signaling axis; Transgene; Signal transduction; T cell; CD8; Notch 1; Transcription factor; Immunology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216007,0.0003408416,0.0003163217,0.0003088209,0.0001919745,0.0003619039,0.0003049791,0.0002939619,0.001544976],"category_scores_gemma":[0.0001435432,0.0002484072,0.0001554742,0.0001906808,0.0004211272,0.0002178122,0.0002338844,0.0006487908,0.0006177744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004316175,"about_ca_system_score_gemma":0.0002568049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006323381,"about_ca_topic_score_gemma":0.001100807,"domain_scores_codex":[0.9997551,0.00003362565,0.00002339358,0.00005672075,0.00007124737,0.00005988992],"domain_scores_gemma":[0.9996911,0.00004105267,0.00008620455,0.0000317317,0.00001454229,0.000135366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006326062,0.00001915827,0.00007651274,0.00001048589,0.000002163533,0.00003269968,0.000007929997,0.00002738111,0.9992163,0.00007379578,0.00001264737,0.0004576918],"study_design_scores_gemma":[0.00001929178,0.000172545,0.001743795,0.000005218846,0.000008461504,0.0002056591,0.0000199009,0.0007029778,0.9957353,0.00005618826,0.001327554,0.00000307658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946507,0.00105847,0.001823567,0.00008768623,0.00002817413,0.00001740472,0.0002938955,0.000141719,0.001898506],"genre_scores_gemma":[0.991771,0.0007303538,0.002106177,0.00005536443,0.00001004585,0.00004042259,0.0004498043,0.00006716368,0.004769618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544976,"threshold_uncertainty_score":0.005168498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00962754471019296,"score_gpt":0.212333800892568,"score_spread":0.2027062561823751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}