{"id":"W1772980645","doi":"10.4049/jimmunol.168.7.3173","title":"Transgenic Expression of Numb Inhibits Notch Signaling in Immature Thymocytes But Does Not Alter T Cell Fate Specification","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"NUMB; Notch signaling pathway; Biology; Cell biology; Cell fate determination; Thymocyte; Notch proteins; Hes3 signaling axis; Transgene; Signal transduction; T cell; CD8; Notch 1; Transcription factor; Immunology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003492532,0.0001007633,0.0001650373,0.00006860956,0.00004478675,0.000003404518,0.0002088357,0.0001983967,0.00005638585],"category_scores_gemma":[0.00001989016,0.00005979364,0.00007058203,0.00006304822,0.0001037439,0.00000867278,0.00003602832,0.0001824596,0.000005338238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001280331,"about_ca_system_score_gemma":0.00001864893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000029278,"about_ca_topic_score_gemma":0.000005148068,"domain_scores_codex":[0.9990705,0.0001932788,0.0004297605,0.00009705387,0.00007298921,0.0001364187],"domain_scores_gemma":[0.9993886,0.00003460921,0.0003356186,0.0001474562,0.0000781402,0.00001552504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000619003,0.00006013616,0.0003831321,0.000008732321,0.00002888705,9.491046e-7,0.0004722799,0.0001475566,0.9966248,0.000003687232,0.00004572742,0.001605091],"study_design_scores_gemma":[0.0006369233,0.0001898347,0.004751966,0.00003275345,0.00001330938,0.00005073286,0.0002602737,0.000008162791,0.9936009,0.00008747636,0.0002936474,0.00007404164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951461,0.003666733,0.0003408805,0.0004662453,0.0001820221,0.00007696448,0.000004399558,0.000001659477,0.0001149812],"genre_scores_gemma":[0.9965652,0.002538538,0.0003985429,0.00005857567,0.00008034517,0.00000103508,0.00001051669,0.000007718573,0.0003395175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004368834,"threshold_uncertainty_score":0.2438314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00962754471019296,"score_gpt":0.212333800892568,"score_spread":0.2027062561823751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}