{"id":"W1774217609","doi":"10.1016/j.ymeth.2015.09.019","title":"Robust generation and expansion of skeletal muscle progenitors and myocytes from human pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Muscular Dystrophy Association","keywords":"Induced pluripotent stem cell; Myogenesis; Cell biology; Progenitor cell; Biology; Skeletal muscle; Myocyte; Stem cell; Embryonic stem cell; Cellular differentiation; Embryoid body; Transplantation; Directed differentiation; Anatomy; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000790294,0.0004289845,0.000329374,0.0006103471,0.0003585758,0.0003955924,0.0004542653,0.0004249138,0.002263166],"category_scores_gemma":[0.0004431179,0.0003878998,0.0003696534,0.000400412,0.0002554003,0.0003475923,0.0008065446,0.0009412514,0.002073646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887114,"about_ca_system_score_gemma":0.0005337144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002422042,"about_ca_topic_score_gemma":0.0008857099,"domain_scores_codex":[0.9993508,0.00007178125,0.0001154186,0.0001023477,0.0003150788,0.00004449575],"domain_scores_gemma":[0.9998236,0.00003541092,0.00002381082,0.00004208116,0.00004764001,0.00002734789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002223068,0.00001916012,0.000139409,0.0000695571,0.00000477988,0.00008449971,0.00003630605,0.0001688569,0.9920929,0.0004484263,0.0004354423,0.00647841],"study_design_scores_gemma":[0.00002078503,0.0001481503,0.001798382,0.00003405049,0.00002711443,0.0003592167,0.00001864211,0.001005748,0.9619487,0.0002254741,0.03439595,0.00001783476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4270601,0.009828068,0.5160641,0.0008069985,0.0008064443,0.003837654,0.00999818,0.002727206,0.02887126],"genre_scores_gemma":[0.4792406,0.01030137,0.4539937,0.0006443258,0.000201984,0.00319437,0.02064565,0.0009432199,0.03083468],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002263166,"threshold_uncertainty_score":0.007571042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08617620759670509,"score_gpt":0.3399067977032325,"score_spread":0.2537305901065274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}